Secretory Leucocyte Protease Inhibitor Antikörper

Produktnummer ABIN2192189

Produktdetails

Target: Secretory Leucocyte Protease Inhibitor

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Applikation: Immunoassay (IA), Immunoprecipitation (IP), Western Blotting (WB)

Sterilität: 0.2 μm filtered

Anwendungsinformationen

Applikationshinweise: For Western blotting dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:10.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS, containing 0.02 % sodium azide and 0.1 % bovine serum albumin.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Product should be stored at 4 °C. Under recommended storage conditions, product is stable for one year.

Haltbarkeit: 12 months

Referenzen

Kramps, van Twisk, Klasen, Dijkman: "Interactions among stimulated human polymorphonuclear leucocytes, released elastase and bronchial antileucoprotease." in: Clinical science (London, England : 1979), Vol. 75, Issue 1, pp. 53-62, (1988) (PubMed).

Antigendetails

Target: Secretory Leucocyte Protease Inhibitor

Hintergrund: The antibody reacts with secretory leukocyte proteinase inhibitor (SLPI, also known as antileukoprotease (ALP)). SLPI is a 11.7 kDa cationic inhibitor of neutrophil elastase and to a lesser extent of cathepsin G. It is locally produced by epithelial cells in the lung, skin and other organs, by Polymorphonuclear leukocytes (PMN) and (in mice) by macrophages. In addition to its proteinase inhibitory properties that may serve to protect against proteolytic injury, it was recently shown that SLPI also displays several other functions such as antimicrobial and anti-inflammatory activities. These appear to be independent of its ability to inhibit PMN serine proteinases. SLPI has also been demonstrated to display antibacterial and antifungal activity at concentrations in which SLPI is present in mucosal secretions including those of the lung. Another possible role for SLPI is inhibition of protein-disulphide isomerase that is considered essential for invasion of a cell by the Human Immunodeficiency Virus (HIV).