Telefon:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@antikoerper-online.de

C1q Antikörper

Dieses Anti-C1q-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von C1q in IHC (fro), IP und IA. Geeignet für Ratte.
Produktnummer ABIN2192169

Kurzübersicht für C1q Antikörper (ABIN2192169)

Target

Alle C1q Antikörper anzeigen
C1q (Complement Fragment C1q (C1q))

Reaktivität

  • 33
  • 11
  • 1
Ratte

Wirt

  • 17
  • 12
  • 5
  • 4
  • 4
  • 1
Kaninchen

Klonalität

  • 26
  • 16
Polyklonal

Konjugat

  • 23
  • 10
  • 7
  • 1
  • 1
  • 1
Dieser C1q Antikörper ist unkonjugiert

Applikation

  • 21
  • 17
  • 16
  • 13
  • 13
  • 9
  • 7
  • 4
  • 4
  • 3
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunoprecipitation (IP), Immunoassay (IA)
  • Sterilität

    0.2 μm filtered
  • Applikationshinweise

    For immunohistology dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50.

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Buffer

    PBS, containing 0.1 % bovine serum albumin and 0.02 % sodium azide.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    4 °C

    Informationen zur Lagerung

    Product should be stored at 4 °C. Under recommended storage conditions, product is stable for one year.

    Haltbarkeit

    12 months
  • Target

    C1q (Complement Fragment C1q (C1q))

    Andere Bezeichnung

    c1q

    Hintergrund

    The polyclonal antibody recognizes rat C1q, a 459 kDa molecule consisting of three individual polypeptide chains. C1q composes together with C1r and C1s the C1 macromolecule, the first component of the classical complement pathway. Interaction of immune complexes with C1q induces a conformational change within the C1 complex, which results in activation of the classical pathway. C1q functions as recognition unit by binding to the heavy chain of IgG or IgM (Fc gamma and Fc micro) provided that the immunoglobulins are bound to their antigen. Furthermore C1q can bind to apoptotic blebs, where it activates the classical complement pathway and mediates phagocytosis. As such, C1q promotes the clearance of apoptotic cells and subsequent exposure of auto antigens, thereby preventing stimulation of the immune system. C1q is predominantly produced by macrophages but also by follicular dendritic cells, interdigitating cells and cells of the monocyte-macrophage lineage. C1q deficiency has a profound effect on host defence and clearance of immune complexes. Absence of C1q may cause autoimmunity by impairment of the clearance of apoptotic cells. Inherited C1q deficiency is also associated with the development of systemic lupus erythematosus (SLE). Aliases 11S protein
Sie sind hier:
Chat with us!