SFTPD Antikörper

Produktnummer ABIN2192111

Produktdetails anti-SFTPD Antikörper

Target: SFTPD (Surfactant Protein D (SFTPD))

Reaktivität: Ratte

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser SFTPD Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoassay (IA)

Sterilität: 0.2 μm filtered

Klon: IIIH3

Anwendungsinformationen

Applikationshinweise: For immunohistology and Western blotting dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:10.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS, containing 0.02 % sodium azide and 0.1 % bovine serum albumin.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Product should be stored at 4 °C. Under recommended storage conditions, product is stable for one year.

Haltbarkeit: 12 months

Referenzen für anti-SFTPD Antikörper (ABIN2192111)

ter Horst, Fijlstra, Sengupta, Walther, Wagenaar: "Spatial and temporal expression of surfactant proteins in hyperoxia-induced neonatal rat lung injury." in: BMC pulmonary medicine, Vol. 6, pp. 8, (2006) (PubMed).

Kasper, Albrecht, Grossmann, Grosser, Schuh, Müller: "Monoclonal antibodies to surfactant protein D: evaluation of immunoreactivity in normal rat lung and in a radiation-induced fibrosis model." in: Experimental lung research, Vol. 21, Issue 4, pp. 577-88, (1995) (PubMed).

Details zu SFTPD

Target: SFTPD (Surfactant Protein D (SFTPD))

Andere Bezeichnung: Surfactant Protein D (SFTPD Produkte)

Synonyme: COLEC7 antikoerper, PSP-D antikoerper, SFTP4 antikoerper, SP-D antikoerper, BDE antikoerper, BDSD antikoerper, HOX4I antikoerper, SPD antikoerper, AI573415 antikoerper, Sftp4 antikoerper, surfactant protein D antikoerper, homeobox D13 antikoerper, surfactant associated protein D antikoerper, SFTPD antikoerper, HOXD13 antikoerper, Sftpd antikoerper, SP-D antikoerper

Hintergrund: The monoclonal antibody IIIH3 recognizes the rat surfactant protein D (SP-D). SP-D belongs to the collectin familiy. These proteins are oligomeric proteins composed of carbohydrate-recognition domains (CRD) attached to collagenous regions. They are structurally similar to the ficolins although they make use of different CRD structures: C-type lectin domain for the collectins. The anti-microbial effector mechanisms of SP-D are direct opsonization, neutralization, and agglutination. Thus limiting the infection and concurrently orchestrating the subsequent adaptive immune response. The lung is the major site of synthesis of SP-D, where the molecules are produced and secreted onto the epithelial surface by alveolar type II cells and unciliated bronchial epithelial cells. SP-D is also found in different epithelial cells of the gastrointeststinal tract and in epithelial cells of exocrine glands. SP-D synthesis and secretion increase significantly after inflammatory stress. Increased amounts of SP-D in lavage and tissue, particularly in type II pneumocytes, in Clara cells and in hyperplastic goblet cells are found in inflamed lungs. The localization of SP-D in endocytic vesicles and in lysosomal granules of alveolar macrophages suggests that a receptor-mediated uptake occurs. SP-D binds to apoptotic neutrophils and enhances their clearance by alveolar macrophages. Monoclonal antibody IIIH3 specific for rat surfactant protein D shows significant cross reactivity with human SP-D.