beta 2 Adrenergic Receptor Antikörper

Produktnummer ABIN2192080

Dieser Maus Monoklonal Antikörper detektiert spezifisch beta 2 Adrenergic Receptor in FACS, Func und IA. Es zeigt Reaktivität gegenüber Proben von Human. Es wurde in 2+ Publikationen zitiert.

Kurzübersicht für beta 2 Adrenergic Receptor Antikörper (ABIN2192080)

Target: beta 2 Adrenergic Receptor (ADRB2) (Adrenergic, beta-2-, Receptor, Surface (ADRB2))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser beta 2 Adrenergic Receptor Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS), Functional Studies (Func), Immunoassay (IA)

Klon: 6H8

Produktdetails anti-beta 2 Adrenergic Receptor Antikörper

Kreuzreaktivität (Details): Cross reactivity: Rat : Yes, Guinea Pig : Yes

Sterilität: 0.2 μm filtered

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: For flow cytometry, dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50. For functional studies, in vitro dilutions have to be optimized in user's experimental setting. Positive Human epidermoid carcinoma cell A431 line control

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS, containing 0.1 % bovine serum albumin

Lagerung: 4 °C

Informationen zur Lagerung: Product should be stored at 4 °C. Under recommended storage conditions, product is stable for at least one year. The exact expiry date is indicated on the label.

Referenzen für anti-beta 2 Adrenergic Receptor Antikörper (ABIN2192080)

Mijares, Lebesgue, Wallukat, Hoebeke: "From agonist to antagonist: Fab fragments of an agonist-like monoclonal anti-beta(2)-adrenoceptor antibody behave as antagonists." in: Molecular pharmacology, Vol. 58, Issue 2, pp. 373-9, (2000) (PubMed).

Lebesgue, Wallukat, Mijares, Granier, Argibay, Hoebeke: "An agonist-like monoclonal antibody against the human beta2-adrenoceptor." in: European journal of pharmacology, Vol. 348, Issue 1, pp. 123-33, (1998) (PubMed).

Details zu beta 2 Adrenergic Receptor

Target: beta 2 Adrenergic Receptor (ADRB2) (Adrenergic, beta-2-, Receptor, Surface (ADRB2))

Andere Bezeichnung: Beta2-Adrenoceptor

Hintergrund: The monoclonal antibody 6H8 recognizes human beta2-adrenoceptor. The b -adrenoceptors can be divided into b1, b2, b3 and b4-adrenoceptors defined in terms of agonist potencies, b2-adrenoceptors displayed a higher selectivity for nor-adrenaline than for adrenaline. B2-receptors are mainly postsynaptic and are located on a number of tissues including blood vessels, bronchi, GIT, skeletal muscle, liver and mast cell. Activation results in vasodilatation, bronchodilation, relaxation of the GIT, glycogenolysis in the liver, tremor in skeletal muscle and inhibition of histamine release from mast cells. Transduction is via G-proteins coupled to the intracellular second messenger adenylate cyclase. B- receptors are positively coupled to adenylate cyclase via activation of Gs G-protein, however activation of the b2-adrenoceptors results in stimulation and inhibition of adenylate cyclase. The b2- receptor selective agonists are widely used in the treatment of asthma and other related bronchospastic conditions. They are commonly used in the treatment of angina pectoris, cardiac arrhythmia and for the long-term treatment of patients who survive myocardial infarction. B-receptor antagonists have also been used as anti-hypertensive for a number of years. Beta -blockers have also proven useful in the treatment of conditions such as migraine, anxiety disorders, hyperthyroidism, alcohol withdrawal and when applied topically are useful in the treatment of glaucoma and ocular hypertension. Immunogen Free peptide Beta2-H19C

Pathways: cAMP Metabolic Process, Synaptic Membrane, Regulation of G-Protein Coupled Receptor Protein Signaling, Brown Fat Cell Differentiation