PLVAP Antikörper

Produktnummer ABIN2192062

Dieses Maus Monoklonal-Antikörper erkennt spezifisch PLVAP in WB, FACS, IHC (fro) und IF. Er zeigt eine Reaktivität gegenüber Human und wurde in 2+ Publikationen erwähnt.

Kurzübersicht für PLVAP Antikörper (ABIN2192062)

Target: PLVAP (Plasmalemma Vesicle Associated Protein (PLVAP))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser PLVAP Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (IF)

Klon: 174-2

Produktdetails anti-PLVAP Antikörper

Sterilität: 0.2 μm filtered

Anwendungsinformationen

Applikationshinweise: For immunohistology, flow cytometry, immunofluorescence and Western blotting, dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS, containing 0.1 % bovine serum albumin and 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Product should be stored at 4 °C. Under recommended storage conditions, product is stable for one year.

Haltbarkeit: 12 months

Referenzen für anti-PLVAP Antikörper (ABIN2192062)

Niemelä, Elima, Henttinen, Irjala, Salmi, Jalkanen: "Molecular identification of PAL-E, a widely used endothelial-cell marker." in: Blood, Vol. 106, Issue 10, pp. 3405-9, (2005) (PubMed).

Carson-Walter, Hampton, Shue, Geynisman, Pillai, Sathanoori, Madden, Hamilton, Walter: "Plasmalemmal vesicle associated protein-1 is a novel marker implicated in brain tumor angiogenesis." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 11, Issue 21, pp. 7643-50, (2005) (PubMed).

Details zu PLVAP

Target: PLVAP (Plasmalemma Vesicle Associated Protein (PLVAP))

Andere Bezeichnung: Plasmalemma Vesicle Associated Protein

Hintergrund: The monoclonal antibody 174/2 reacts with human plasmalemma vesicle associated protein (PLVAP), also known as PV1, PAL-E and FELS. PLVAP is a 60 kDa type II transmembrane glycoprotein which tends to form homodimers. PLVAP is widely expressed in the vasculature of normal tissues. The vascular staining pattern of PLVAP is quite unique among the endothelial cell antigens, since expression of other antigens (like ICAM-1, P-selectin, E-selectin or VCAM-1) is not limited to vascular endothelial cells. PLVAP expression in the vascular endothelial cells of the CNS is lost in association with formation of an intact blood-brain barrier. However, in the endothelium of human brain tumors expression of PLVAP is specifically up-regulated, making it a suitable antiangiogenic target for brain tumor therapy and cerebral edema. Furthermore, PLVAP is expressed in the vasculature of most other human tumors and as such useful as marker for tumor angiogenesis.