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AOC3 Antikörper (Amine Oxidase, Copper Containing 3 (Vascular Adhesion Protein 1)) Primary Antibody

AOC3 Reaktivität: Human Func, IHC (fro), FACS Wirt: Maus Monoclonal 174-5 unconjugated
Pubmed (2 Referenzen)
Produktnummer ABIN2192061
$797.69
Zzgl. Versandkosten $45.00
100 μg
Lieferung in 6 bis 8 Werktagen
  • Target Alle AOC3 Antikörper anzeigen
    AOC3
    Reaktivität
    • 65
    • 5
    • 4
    Human
    Wirt
    • 47
    • 9
    • 9
    • 2
    Maus
    Klonalität
    • 56
    • 10
    • 1
    Monoklonal
    Konjugat
    • 29
    • 6
    • 6
    • 5
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser AOC3 Antikörper ist unkonjugiert
    Applikation
    • 39
    • 37
    • 18
    • 13
    • 13
    • 10
    • 8
    • 6
    • 5
    • 4
    • 3
    • 1
    • 1
    • 1
    Functional Studies (Func), Immunohistochemistry (Frozen Sections) (IHC (fro)), Flow Cytometry (FACS)
    Kreuzreaktivität (Details)
    Cross reactivity: Rat : Yes
    Sterilität
    0.2 μm filtered
    Klon
    174-5
    Isotyp
    IgG1
  • Applikationshinweise
    For immunohistochemistry and flow cytometry, dilutions to be used depend on detection system chemistry, , applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50. For functional studies, in vitro dilutions have to be optimized in user's experimental setting. Positive Ax cells stably transfected with VAP-1 cDNA. (Ref. 1) VAP control Negative Mock transfected Ax cells. (Ref. 1) control
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Buffer
    PBS, containing 0.1 % bovine serum albumin.
    Lagerung
    4 °C
    Informationen zur Lagerung
    Product should be stored at 4 °C. Under recommended storage conditions, product is stable for at least one year. The exact expiry date is indicated on the label.
  • Autio, Ujula, Luoto, Salomäki, Jalkanen, Roivainen: "PET imaging of inflammation and adenocarcinoma xenografts using vascular adhesion protein 1 targeting peptide 68Ga-DOTAVAP-P1: comparison with 18F-FDG." in: European journal of nuclear medicine and molecular imaging, Vol. 37, Issue 10, pp. 1918-25, (2010) (PubMed).

    Martelius, Salaspuro, Salmi, Krogerus, Höckerstedt, Jalkanen, Lautenschlager: "Blockade of vascular adhesion protein-1 inhibits lymphocyte infiltration in rat liver allograft rejection." in: The American journal of pathology, Vol. 165, Issue 6, pp. 1993-2001, (2004) (PubMed).

  • Target
    AOC3
    Andere Bezeichnung
    Vascular Adhesion Protein-1 (AOC3 Produkte)
    Synonyme
    HPAO, SSAO, VAP-1, VAP1, aoc2, BOLAO, amine oxidase, copper containing 3, amine oxidase, copper containing 3 L homeolog, AOC3, aoc3.L, Aoc3
    Hintergrund
    The monoclonal antibody 174-5 recognises human Vascular Adhesion Protein-1 (VAP-1), which is a glycosylated homodimeric membrane protein consisting of two 90 kDa subunits connected by disulfide bonds. It contains a short N-terminal cytoplasmic tail, a single membrane-spanning domain and a large extracellular part. A soluble form of VAP-1 (sVAP-1) has been described, which presumably results from the proteolytic cleavage of membrane-bound VAP-1. Structurally VAP-1 belongs to enzymes called semicarbamizide-sensitive amine oxidases, which contain copper as a cofactor. These enzymes deaminate primary amines in a reaction producing hydrogen peroxide, aldehyde, and ammonia. VAP-1 is present in endothelial cells, smooth muscle cells, adipocytes, and in follicular dendritic cells. In endothelial cells the majority of VAP-1 is stored within intracellular granules and translocated to the surface upon inflammation where it regulates leukocyte tissue infiltration. Furthermore, the end- products formed by VAP-1 can also regulate leukocyte migration by signaling effects, have insulin-like effects in energy metabolism, and can cause vascular damage by direct cytotoxicity. Elevated sVAP- 1serum levels have been described in several inflammatory diseases as well as colorectal cancer. Moreover, diminished insulin secretion appears to increase the concentration of soluble VAP-1 in plasma. Therefore, VAP-1 might be an interesting diagnostic marker as well therapeutic target for modulating inflammation.The monoclonal antibody 174-5 has been shown to cross-react with rat VAP- 1 and to inhibit lymphocyte infiltration in rat liver allograft rejection. Aliases membrane primary amine oxidase, AOC3, SSAO Immunogen Purified vessels from human peripheral lymph nodes (ref 1)
    Pathways
    Feeding Behaviour
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