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C1QBP Antikörper (Complement Component 1, Q Subcomponent Binding Protein) Primary Antibody

C1QBP Reaktivität: Human Func, IA, FACS, IF, IP, WB Wirt: Maus Monoclonal 74-5-2 unconjugated
Pubmed (4 Referenzen)
Produktnummer ABIN2191879
$605.98
Zzgl. Versandkosten $45.00
100 μg
Lieferung in 6 bis 8 Werktagen
  • Target Alle C1QBP Antikörper anzeigen
    C1QBP
    Reaktivität
    • 68
    • 40
    • 27
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    Human
    Wirt
    • 77
    • 19
    • 1
    Maus
    Klonalität
    • 79
    • 18
    Monoklonal
    Konjugat
    • 51
    • 13
    • 12
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser C1QBP Antikörper ist unkonjugiert
    Applikation
    • 71
    • 31
    • 23
    • 15
    • 15
    • 15
    • 13
    • 13
    • 13
    • 11
    • 8
    • 7
    • 4
    • 3
    • 2
    • 2
    Functional Studies (Func), Immunoassay (IA), Flow Cytometry (FACS), Immunofluorescence (IF), Immunoprecipitation (IP), Western Blotting (WB)
    Kreuzreaktivität (Details)
    Cross reactivity: Rat : Yes
    Sterilität
    0.2 μm filtered
    Klon
    74-5-2
    Isotyp
    IgG1
  • Applikationshinweise
    For flow cytometry and Western blotting, dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50. For functional studies, in vitro dilutions have to be optimized in user's experimental setting. Website:
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Buffer
    PBS, containing 0.1 % bovine serum albumin.
    Lagerung
    4 °C
    Informationen zur Lagerung
    Product should be stored at 4 °C. Under recommended storage conditions, product is stable for one year.
    Haltbarkeit
    12 months
  • Sansonno, Tucci, Ghebrehiwet, Lauletta, Peerschke, Conteduca, Russi, Gatti, Sansonno, Dammacco: "Role of the receptor for the globular domain of C1q protein in the pathogenesis of hepatitis C virus-related cryoglobulin vascular damage." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 183, Issue 9, pp. 6013-20, (2009) (PubMed).

    Peerschke, Bayer, Ghebrehiwet, Xiong: "gC1qR/p33 blockade reduces Staphylococcus aureus colonization of target tissues in an animal model of infective endocarditis." in: Infection and immunity, Vol. 74, Issue 8, pp. 4418-23, (2006) (PubMed).

    Ghebrehiwet, Lim, Kumar, Feng, Peerschke: "gC1q-R/p33, a member of a new class of multifunctional and multicompartmental cellular proteins, is involved in inflammation and infection." in: Immunological reviews, Vol. 180, pp. 65-77, (2001) (PubMed).

    Ghebrehiwet, Lu, Zhang, Lim, Eggleton, Leigh, Reid, Peerschke: "Identification of functional domains on gC1Q-R, a cell surface protein that binds to the globular "heads" of C1Q, using monoclonal antibodies and synthetic peptides." in: Hybridoma, Vol. 15, Issue 5, pp. 333-42, (1997) (PubMed).

  • Target
    C1QBP
    Abstract
    C1QBP Produkte
    Synonyme
    SF2, X38k, gC1qR, C1QBP, GC1QBP, HABP1, SF2p32, gC1Q-R, p32, AA407365, AA986492, D11Wsu182e, P32, gC1qBP, Habp1, complement C1q binding protein, complement component 1, q subcomponent binding protein S homeolog, complement component 1, q subcomponent binding protein, C1QBP, c1qbp.S, LOC100227158, C1qbp
    Hintergrund
    The monoclonal antibody 74.5.2 recognizes a cell membrane C1q binding molecule that recognises the globular heads of C1q. It is also present in plasma and the extracellular matrix. The molecule is an unusually acidic, single chain protein with an apparent molecular weight of 33 kDa. It does not possess a conventional sequence motif compatible with a membrane spanning segment nor a consensus site for a GPI anchor. gC1qR migrates as a single chain under both reducing and non-reducing conditions, but it behaves as an oligomer on gel-filtration in non-dissociating conditions. Its multimer formation may be a critical process by which the gC1qR molecule increases its affinity for multivalent ligands such as C1q. gC1qR has been shown to inhibit complement activation by preventing the binding of C1q to antibodies, suggesting that the binding site for gC1qR and the binding site for immune complexes, which are present on the C1q globular 'heads', may be located at the same position. gC1qR is capable of interacting with several proteins involved in blood clotting, namely, thrombin, prothrombin, the heparinbinding form of vitronectin, the ternary complex, vitronectin-thrombin-antithrombin, as well as high-molecular-weight kininogen and Hageman factor. Besides its role in the complement pathway, gC1qR participates in enhancement of Fc-receptor and CR1-mediated phagocytosis, procoagulant activity on platelets, and chemotactic activity on mast cells, eosinophils, neutrophils, and fibroblasts. gC1qR is expressed on a wide variety of cells and can serve as a binding site for plasma and microbial proteins. Its antigenic sites may be cryptic on cells in suspension but become exposed when the cells are fixed by bifunctional cross-linkers. Probably it is also expressed on the cell membrane as a tetramer. Crosslinking or activation may thus bring about a tetrameric assembly of gC1qR followed by a conformational change within the molecule, thereby exposing epitopes which are otherwise hidden. A form of gC1qR is also found inside the cell. Intracellular gC1qR has been shown to bind the cytoplasmic tail of the α1B-adrenergic receptor and to PKCμ. The monoclonal antibody 74.5.2 is directed against epitopes in the XC15 peptide that contains a binding site for high-molecular-weight kininogen and Factor XII.
    Pathways
    Ribonucleoprotein Complex Subunit Organization, Ribosome Assembly
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