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C5a Receptor Antikörper (C5AR) Primary Antibody

C5AR Reaktivität: Maus FACS, WB Wirt: Ratte Monoclonal 10-92 unconjugated
Pubmed (1 reference)
Produktnummer ABIN2191827
$867.55
Zzgl. Versandkosten $45.00
100 μg
Lieferung in 6 bis 8 Werktagen
  • Target See all C5a Receptor (C5AR) products
    C5a Receptor (C5AR)
    Reaktivität
    • 2
    • 1
    • 1
    Maus
    Wirt
    • 3
    • 1
    Ratte
    Klonalität
    • 4
    Monoklonal
    Applikation
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    Flow Cytometry (FACS), Western Blotting (WB)
    Sterilität
    0.2 μm filtered
    Klon
    10-92
  • Applikationshinweise
    For immunohistology, Western blotting and flow cytometry, dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Buffer
    PBS, containing 0.1 % bovine serum albumin and 0.02 % sodium azide.
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C
    Informationen zur Lagerung
    Product should be stored at 4 °C. Under recommended storage conditions, product is stable for one year.
    Haltbarkeit
    12 months
  • Soruri, Kim, Kiafard, Zwirner: "Characterization of C5aR expression on murine myeloid and lymphoid cells by the use of a novel monoclonal antibody." in: Immunology letters, Vol. 88, Issue 1, pp. 47-52, (2003) (PubMed).

  • Target
    C5a Receptor (C5AR)
    Andere Bezeichnung
    c5a Receptor (C5AR Produkte)
    Hintergrund
    The monoclonal antibody 10/92 recognizes the mouse receptor C5a (C5aR, CD88). The mouse anaphylatoxin C5a is a 74-residu glycopolypeptide which is generated by proteolytic cleavage of the complement factor C5 in the course of complement activation. A variety of biological effects evoked by C5a could be demonstrated, rendering this molecule an important mediator of inflammation, with granulocytes and macrophages as the main target cells. All cellular responses to C5a are specifically mediated by interactions with the membrane bound C5a receptor, a seven transmembrane GTP- binding-protein-coupled receptor that belongs to the rhodopsin supergene family. The 45 kDa C5a receptor is expressed by neutrophils, monocytes/macrophages, dendritic cells, astrocytes and microglia. In contrast, C5a receptor is not detectable on resting or stimulated murine T and B lymphocytes. The monoclonal antibody 10/92 does not inhibit the binding of C5a to its receptor. Aliases C5aR1, CD88 Immunogen RBL-2H3 transfectants expressing murine C5aR
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