C5a Receptor Antikörper

Produktnummer ABIN2191827

Dieses Anti-C5a Receptor-Antikörper ist ein Ratte Monoklonal-Antikörper zur Detektion von C5a Receptor in FACS und WB. Geeignet für Maus. Dieses Primary Antibody wurde in 1 Publikation zitiert.

Kurzübersicht für C5a Receptor Antikörper (ABIN2191827)

Target: C5a Receptor (C5AR)

Reaktivität: Maus

Wirt: Ratte

Klonalität: Monoklonal

Konjugat: Dieser C5a Receptor Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS), Western Blotting (WB)

Klon: 10-92

Produktdetails anti-C5a Receptor Antikörper

Sterilität: 0.2 μm filtered

Anwendungsinformationen

Applikationshinweise: For immunohistology, Western blotting and flow cytometry, dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS, containing 0.1 % bovine serum albumin and 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Product should be stored at 4 °C. Under recommended storage conditions, product is stable for one year.

Haltbarkeit: 12 months

Referenzen für anti-C5a Receptor Antikörper (ABIN2191827)

Soruri, Kim, Kiafard, Zwirner: "Characterization of C5aR expression on murine myeloid and lymphoid cells by the use of a novel monoclonal antibody." in: Immunology letters, Vol. 88, Issue 1, pp. 47-52, (2003) (PubMed).

Details zu C5a Receptor

Target: C5a Receptor (C5AR)

Andere Bezeichnung: c5a Receptor

Hintergrund: The monoclonal antibody 10/92 recognizes the mouse receptor C5a (C5aR, CD88). The mouse anaphylatoxin C5a is a 74-residu glycopolypeptide which is generated by proteolytic cleavage of the complement factor C5 in the course of complement activation. A variety of biological effects evoked by C5a could be demonstrated, rendering this molecule an important mediator of inflammation, with granulocytes and macrophages as the main target cells. All cellular responses to C5a are specifically mediated by interactions with the membrane bound C5a receptor, a seven transmembrane GTP- binding-protein-coupled receptor that belongs to the rhodopsin supergene family. The 45 kDa C5a receptor is expressed by neutrophils, monocytes/macrophages, dendritic cells, astrocytes and microglia. In contrast, C5a receptor is not detectable on resting or stimulated murine T and B lymphocytes. The monoclonal antibody 10/92 does not inhibit the binding of C5a to its receptor. Aliases C5aR1, CD88 Immunogen RBL-2H3 transfectants expressing murine C5aR