TSPAN12 Antikörper (PE)

Produktnummer ABIN2179842

Dieses Anti-TSPAN12-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von TSPAN12 in FACS. Geeignet für Human, Ratte und Maus.

Kurzübersicht für TSPAN12 Antikörper (PE) (ABIN2179842)

Target: TSPAN12 (Tetraspanin 12 (TSPAN12))

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TSPAN12 Antikörper ist konjugiert mit PE

Applikation: Flow Cytometry (FACS)

Produktdetails anti-TSPAN12 Antikörper (PE)

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human TSPAN12

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: FCM: (1:20-100)
Optimal working dilution should be determined by the investigator.

Kommentare:

Exitation/Emission: 480,565nm/578nm

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 100 μg/mL BSA, 50 % glycerol and 0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at 4 °C for 12 months.

Details zu TSPAN12

Target: TSPAN12 (Tetraspanin 12 (TSPAN12))

Andere Bezeichnung: Tspan12

Hintergrund: TSPAN12 is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. It is a regulator of cell surface receptor signal transduction and plays a central role in retinal vascularization by regulating norrin (NDP) signal transduction. It acts in concert with norrin (NDP) to promote FZD4 multimerization and subsequent activation of FZD4, leading to promote accumulation of beta-catenin (CTNNB1) and stimulate LEF/TCF-mediated transcriptional programs. It also acts as a regulator of membrane proteinases such as ADAM10 and MMP14/MT1-MMP. It activates ADAM10-dependent cleavage activity of amyloid precursor protein (APP) and activates MMP14/MT1-MMP-dependent cleavage activity.
Synonyms: TSPAN 12, NET 2, NET2, Tetraspan NET 2, Tetraspanin 12, Tetraspanin12, TM4SF12, Transmembrane 4 superfamily member 12, TSN12_HUMAN.

Gen-ID: 23554