THRAP3 Antikörper (PE)

Produktnummer ABIN2179657

Produktdetails anti-THRAP3 Antikörper (PE)

Target: THRAP3 (Thyroid Hormone Receptor Associated Protein 3 (THRAP3))

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser THRAP3 Antikörper ist konjugiert mit PE

Applikation: Western Blotting (WB)

Kreuzreaktivität: Human, Ratte

Homologie: Mouse,Dog,Cow,Pig,Horse,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Thrap3/TRAP150

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: FCM: (1:20-100)
Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Details zu THRAP3

Target: THRAP3 (Thyroid Hormone Receptor Associated Protein 3 (THRAP3))

Andere Bezeichnung: Thrap3 (THRAP3 Produkte)

Hintergrund:

Synonyms: Thrap3, Thyroid hormone receptor associated protein 3, Thyroid hormone receptor-associated protein 3, Thyroid hormone receptor-associated protein complex 150 kDa component, Thyroid hormone receptor-associated protein complex,TR150_HUMAN, Trap150.

Background: In mammalian cells, transcription is regulated in part by high molecular weight coactivating complexes that mediate signaling between transcriptional activators and initiation factors. These complexes include the thyroid hormone receptor-associated protein (TRAP) complex, which interacts with thyroid receptors (TR), vitamin D receptors and other steroid receptors to facilitate hormone induced transcriptional activation. The TRAP complex consists of numerous proteins ranging in size including TRAP95, TRAP100, TRAP150, TRAP220 and TRAP230, that are characterized by the presence of a nuclear receptor recognition motif which mediates the ligand-dependent binding of TRAP proteins to the nuclear receptors. TRAP220 and TRAP100 are widely expressed and most abundantly detected in skeletal muscle, heart and placenta. TRAP95, TRAP150 and TRAP230 facilitate TR induced transcription by associating with an additional transcriptional coactivating complex SMCC (SRB and MED protein cofactor complex), which consists of various subunits that share homology with several components of the yeast transcriptional mediator complexes.

Gen-ID: 389541

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway