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SLK Antikörper (STE20-Like Kinase) pTyr530 (Biotin) Primary Antibody

SLK Reaktivität: Maus, Ratte IHC (fro), IHC (p) Wirt: Kaninchen Polyclonal Biotin
Produktnummer ABIN2179280
$418.77
Zzgl. Versandkosten $45.00
100 μL
Lieferung in 11 bis 16 Werktagen
  • Target Alle SLK Antikörper anzeigen
    SLK
    Bindungsspezifität
    • 15
    • 15
    • 14
    • 6
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pTyr530
    Reaktivität
    • 47
    • 37
    • 21
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Maus, Ratte
    Wirt
    • 59
    • 2
    Kaninchen
    Klonalität
    • 59
    • 2
    Polyklonal
    Konjugat
    • 17
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 1
    Dieser SLK Antikörper ist konjugiert mit Biotin
    Applikation
    • 39
    • 39
    • 20
    • 11
    • 10
    • 9
    • 8
    • 6
    • 3
    • 3
    • 3
    • 1
    Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Homologie
    Human,Dog,Cow,Pig,Chicken,Rabbit
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic phosphopeptide derived from human FYN around the phosphorylation site of Tyr530
    Isotyp
    IgG
  • Applikationshinweise
    IHC-P 1:200-400
    IHC-F 1:100-500
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C
    Haltbarkeit
    12 months
  • Target
    SLK
    Andere Bezeichnung
    SLK (SLK Produkte)
    Synonyme
    BcDNA:LD05623, CG40293, Dmel\\CG40293, LD05623, LOSK, STK2, bA16H23.1, se20-9, 9A2, AV021402, AW411554, Etk4, SMAK, Stk2, mKIAA0204, mSLK, STE20 like kinase, Ste20-like kinase, STE20-like kinase, SLK, Stlk, Slk
    Hintergrund

    Fyn is a membrane-associated, non-receptor protein tyrosine kinase approximately 59 kDa, which belongs to the Src family of cytoplasmic tyrosine kinases. Fyn is very strongly similar to mouse Fyn, v-yes and c-src. Fyn is expressed predominately in tissues of neuronal and hematopoietic origin. Neuronal Fyn and hematopoietic Fyn differ at the junction of the SH2 and kinase domains due to tissue specific alternative splicing. Fyn has been shown to be involved in B cell and T cell activation as well as keratinocyte differentiation. In T cells, Fyn associates with the T-cell antigen receptor and Thy1. The unique N terminal domain of Fyn interacts with the CD3 and eta chains of the TcR. Fyn can bind to other proteins (p82 and p116) through its SH2 and SH3 domains, which may act as substrates or regulators of Fyn activity. Fyn is highly expressed in brain suggesting that it may have a role in the sensory nervous network and in myelination at early stages of CNS formation.

    Subcellular location: Cytoplasm, Nucleus, Cell membrane

    Synonyms: Fyn phospho Y530, p-Fyn phospho Y530, C syn protooncogene, FYN oncogene related to SRC FGR YES_ MGC45350_ OKT3 induced calcium influx regulator_ P59 FYN, Protein tyrosine kinase fyn, Proto oncogene tyrosine protein kinase fyn, Protooncogene Syn, SLK, Src like kinase, Src yes related novel gene, Src/yes related novel gene, SYN, FYN, Tyrosine kinase p59fyn T, Tyrosine kinase p59fynT.

    Gen-ID
    2534
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