PROS1 Antikörper (PE)

Produktnummer ABIN2178727

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch PROS1 in WB. Er zeigt eine Reaktivität gegenüber Human, Ratte und Maus.

Kurzübersicht für PROS1 Antikörper (PE) (ABIN2178727)

Target: PROS1 (PROS) (Protein S (PROS))

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PROS1 Antikörper ist konjugiert mit PE

Applikation: Western Blotting (WB)

Produktdetails anti-PROS1 Antikörper (PE)

Kreuzreaktivität: Human, Maus, Ratte

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Protein S/PROS

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: FCM: (1:20-100)
Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Details zu PROS1

Target: PROS1 (PROS) (Protein S (PROS))

Andere Bezeichnung: Protein S

Hintergrund:

Synonyms: Preproprotein S, Propiece of latent protein S, PROS 1, PROS, PROS_HUMAN, PROS1, Protein S alpha, Protein Sa, PS 21, PS 22, PS 23, PS 24, PS 25, PS 26, PS21, PS22, PS23, PS24, PS25, PS26, PSA, Vitamin K dependent protein S, Vitamin K-dependent protein S.

Background: Protein S (PROS) is a vitamin K-dependent plasma protein that inhibits blood clotting by serving as a cofactor for activated protein C (APC) and facilitates clearance of early apoptotic cells. In the plasma, circulating Protein S becomes inactive upon complexing with C4b-binding protein (C4BP), 60-70 % of Protein S circulates in complex with C4BP. Calcium-dependent association of C4BP-Protein S with apoptotic cells influences the regulation of complement activation. Protein S has APC-independent anticoagulant activity through direct inhibition of prothrombin activation via interactions with Factor X A, Factor V A and phospholipids. Autosomal dominant Protein S deficiency (levels 15 to 37 % of normal) correlates with severe recurrent venous thrombosis.

Gen-ID: 5627

UniProt: P07225