LCMV Protein Z (AA 21-80) Antikörper (Cy5)

Produktnummer ABIN2177291

Produktdetails

Target: LCMV Protein Z

Bindungsspezifität: AA 21-80

Reaktivität: Lymphotic Choriomeniningitis Virus (LCMV), Virus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Cy5

Applikation: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Kreuzreaktivität: Virus

Kreuzreaktivität (Details): Armstrong Strain LCMV

Produktmerkmale: Antibody is specific for: Armstrong Strain LCMV

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from LCMV Protein Z

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Antigendetails

Target: LCMV Protein Z

Substanzklasse: Viral Protein

Hintergrund:

Synonyms: Lymphocytic choriomeningitis virus.RING finger protein Z, Protein Z, Zinc-binding protein, Z_LYCVA.

Background: Plays a crucial role in virion assembly and budding. Expressed late in the virus life cycle, it acts as an inhibitor of viral transcription and RNA synthesis by interacting with the viral polymerase L (By similarity). Presumably recruits the NP encapsidated genome to cellular membranes at budding sites via direct interaction with NP. Plays critical roles in the final steps of viral release by interacting with host TSG101, a member of the vacuolar protein-sorting pathway and using other cellular host proteins involved in vesicle formation pathway. The budding of the virus progeny occurs after association of protein Z with the viral glycoprotein complex SSP-GP1-GP2 at the cell periphery, step that requires myristoylation of protein Z. Also selectively represses protein production by associating with host eIF4E

UniProt: P18541