H3 Histone Family Member E Pseudogene (acLys10), (pSer11) Antikörper (Cy7)

Produktnummer ABIN2175107

Der Kaninchen Polyklonal anti-H3 Histone Family Member E Pseudogene Antikörper wird verwendet zum Nachweis von H3 Histone Family Member E Pseudogene in Proben von Human, Maus und Ratte. Er wurde validiert für WB.

Kurzübersicht für H3 Histone Family Member E Pseudogene (acLys10), (pSer11) Antikörper (Cy7) (ABIN2175107)

Target: H3 Histone Family Member E Pseudogene

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Cy7

Applikation: Western Blotting (WB)

Produktdetails

Bindungsspezifität: acLys10, pSer11

Kreuzreaktivität: Human

Homologie: Mouse,Rat,Cow,Pig,Rabbit,Drosophila

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Acetyl and Histone H3 (Ac-Lys10/p-Ser11)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF(IHC-P) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Antigendetails

Target: H3 Histone Family Member E Pseudogene

Hintergrund:

Synonyms: H3 histone family member E pseudogene, H3F3, HIST3H3, Histone H3 3 pseudogene.

Background: Modulation of the chromatin structure plays an important role in the regulation of transcription in eukaryotes. The nucleosome, made up of four core histone proteins (H2A, H2B, H3 and H4), is the primary building block of chromatin. The N-terminal tail of core histones undergoes different posttranslational modifications including acetylation, phosphorylation and methylation. These modifications occur in response to cell signal stimuli and have a direct effect on gene expression. In most species, the histone H2B is primarily acetylated at lysines 5, 12, 15 and 20. Histone H3 is primarily acetylated at lysines 9, 14, 18 and 23. Acetylation at lysine 9 appears to have a dominant role in histone deposition and chromatin assembly in some organisms. Phosphorylation at Ser10 of histone H3 is tightly correlated with chromosome condensation during both mitosis and meiosis.