PLA2G6 Antikörper (PE)

Produktnummer ABIN2172205

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch PLA2G6 in WB, IF (cc) und IF (p). Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für PLA2G6 Antikörper (PE) (ABIN2172205)

Target: PLA2G6 (Phospholipase A2, Group VI (Cytosolic, Calcium-Independent) (PLA2G6))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PLA2G6 Antikörper ist konjugiert mit PE

Applikation: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Produktdetails anti-PLA2G6 Antikörper (PE)

Verwendungszweck: CaIPLA2 Polyclonal Antibody, PE Conjugated

Homologie: Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human CaI-PLA2/PLA2G6

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB(1:300-5000), IF(IHC-P)(1:50-200), IF(IHC-F)(1:50-200), IF(ICC)(1:50-200)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Details zu PLA2G6

Target: PLA2G6 (Phospholipase A2, Group VI (Cytosolic, Calcium-Independent) (PLA2G6))

Hintergrund:

Synonyms: GVI, PLA2, INAD1, NBIA2, iPLA2, NBIA2A, NBIA2B, PARK14, PNPLA9, CaI-PLA2, IPLA2-VIA, iPLA2beta, 85/88 kDa calcium-independent phospholipase A2, Group VI phospholipase A2, GVI PLA2, Intracellular membrane-associated calcium-independent phospholipase A2 beta, iPLA2-beta, Patatin-like phospholipase domain-containing protein 9, PLA2G6, PLPLA9

Background: Catalyzes the release of fatty acids from phospholipids. It has been implicated in normal phospholipid remodeling, nitric oxide-induced or vasopressin-induced arachidonic acid release and in leukotriene and prostaglandin production. May participate in fas mediated apoptosis and in regulating transmembrane ion flux in glucose-stimulated B-cells. Has a role in cardiolipin (CL) deacylation. Required for both speed and directionality of monocyte MCP1/CCL2-induced chemotaxis through regulation of F-actin polymerization at the pseudopods. Isoform ankyrin-iPLA2-1 and isoform ankyrin-iPLA2-2, which lack the catalytic domain, are probably involved in the negative regulation of iPLA2 activity.

Gen-ID: 8398

UniProt: O60733

Pathways: Positive Regulation of Peptide Hormone Secretion