Glyco Protein G Antikörper

Produktnummer ABIN1993838

Produktdetails

Target: Glyco Protein G

Reaktivität: Rabies Virus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Unkonjugiert

Applikation: ELISA, Western Blotting (WB), Immunohistochemistry (IHC)

Aufreinigung: Caprylic Acid Ammonium Sulfate Precipitation

Immunogen: Recombinant Rabies virus Glycoprotein G protein

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working concentration should be determinde by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: 0.03 % Proclin 300, 53 % Glycerol, 0.01 M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin^TM: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handhabung: Avoid repeated freeze.

Lagerung: -20 °C/-80 °C

Informationen zur Lagerung: Upon delivery aliquot and store at -20 °C or -80 °C.

Referenzen

Starodubova, Kuzmenko, Pankova, Latanova, Preobrazhenskaya, Karpov: "[A DNA Construct That Encodes the Rabies Virus Consensus Glycoprotein with a Proteasome Degradation Signal Induces Antibody Production with IgG2A Subtype Predominance]." in: Molekuliarnaia biologiia, Vol. 52, Issue 3, pp. 527-532, (2018) (PubMed).

Antigendetails

Target: Glyco Protein G

Synonyme: transmembrane glycoprotein G antikoerper, RABVgp4 antikoerper

Substanzklasse: Viral Protein

Hintergrund: Attaches the virus to host cellular receptor, inducing endocytosis of the virion. In the endosome, the acidic pH induces conformational changes in the glycoprotein trimer, which trigger fusion between virus and cell membrane. There is convincing in vitro evidence that the muscular form of the nicotinic acetylcholine receptor (nAChR), the neuronal cell adhesion molecule (NCAM), and the p75 neurotrophin receptor (p75NTR) bind glycoprotein G and thereby facilitate rabies virus entry into cells.
Synonyms: G

UniProt: P03524