Endothelin 1 Antikörper (C-Term)

Produktnummer ABIN198265

Dieses Maus Monoklonal-Antikörper erkennt spezifisch Endothelin 1 in IHC, RIA und IHC (fro). Er zeigt eine Reaktivität gegenüber Human und Affe.

Kurzübersicht für Endothelin 1 Antikörper (C-Term) (ABIN198265)

Target: Endothelin 1 (EDN1)

Reaktivität: Human, Affe

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Endothelin 1 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), Radioimmunoassay (RIA), Immunohistochemistry (Frozen Sections) (IHC (fro))

Klon: 1C4

Produktdetails anti-Endothelin 1 Antikörper

Bindungsspezifität: C-Term

Spezifität: Recognizes human endothelin 1 (ET-1). Endothelin-1 in it's precursor form is a 212 amino acid protein with a 17 aa signal peptide, an N-terminal pro-peptide region and a C-terminal pro-peptide region flanking the endothelin peptides, big endothelin-1 (38aa), the precursor of the smaller endothelin peptide which is cleaved by endothelin converting enzyme to produce the active endothelin-1 (21aa) peptide and a c-terminal fragment. Endothelin-1 is a potent vasoconstrictor with a molecular weight of approximately 25 kD. Shows less than 10 % reactivity with endothelin 3. Plasma levels of both endothelin-1 and big endothelin-1 are useful as predictors for survival of patients with congestive heart failure. However, the half life of the endothlin1 peptide in human plasma is very short (c1.0 mins) and measurement of big-endothelin-1 may be a more reliable measure of the endothelin secretory pathway activity.

Aufreinigung: Protein A purified

Immunogen: C-terminal fragment of human endothelin 1.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

Target Species of Antibody: Human

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: PBS,  pH 7.2, 0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Short term: -20°C
Long term: -20°C.

Details zu Endothelin 1

Target: Endothelin 1 (EDN1)

Andere Bezeichnung: EDN1 / Endothelin 1

Hintergrund: Name/Gene ID: EDN1
Family: Hormone

Synonyms: EDN1, Endothelin 1, Endothelin-1, ET1, Preproendothelin-1, PPET1, HDLCQ7

Gen-ID: 1906

UniProt: P05305

Pathways: Hormone Transport, Negative Regulation of Hormone Secretion, Regulation of Systemic Arterial Blood Pressure by Hormones, cAMP Metabolic Process, Regulation of Muscle Cell Differentiation, Regulation of G-Protein Coupled Receptor Protein Signaling, Regulation of Cell Size