CCR7 Antikörper (PE)

Produktnummer ABIN1981861

Dieses Ratte Monoklonal-Antikörper erkennt spezifisch CCR7 in FACS. Er zeigt eine Reaktivität gegenüber Maus und wurde in 3+ Publikationen erwähnt.

Kurzübersicht für CCR7 Antikörper (PE) (ABIN1981861)

Target: CCR7 (Chemokine (C-C Motif) Receptor 7 (CCR7))

Reaktivität: Maus

Wirt: Ratte

Klonalität: Monoklonal

Konjugat: Dieser CCR7 Antikörper ist konjugiert mit PE

Applikation: Flow Cytometry (FACS)

Klon: 4B12

Produktdetails anti-CCR7 Antikörper (PE)

Verwendungszweck: Anti-Ms CD197 PE

Spezifität: The rat monoclonal antibody 4B12 recognizes an extracellular epitope of murine CD197 / CCR7 (chemokine receptor 7), a 43 kDa G-protein-coupled receptor for chemokines CCL19 and CCL21.

Kreuzreaktivität (Details): Mouse

Aufreinigung: Purified antibody is conjugated with R-phycoerythrin (PE) under optimum conditions. Unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.

Immunogen: Murine CD197-transfected RBL-2H3 cells

Isotyp: IgG2a kappa

Anwendungsinformationen

Applikationshinweise: Flow cytometry: Recommended dilution: 1-5 μg/mL.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Do not freeze. Avoid prolonged exposure to light.
Do not use after expiration date stamped on vial label.
Short-term exposure to room temperature should not affect the quality of the reagent. However, if reagent is stored under any conditions other than those specified, the conditions must be verified by the user.

Lagerung: 4 °C

Informationen zur Lagerung: Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

Referenzen für anti-CCR7 Antikörper (PE) (ABIN1981861)

Adachi, Osada, Nakamura, Tamada, Hamano: "Unique T cells with unconventional cytokine profiles induced in the livers of mice during Schistosoma mansoni infection." in: PLoS ONE, Vol. 8, Issue 12, pp. e82698, (2013) (PubMed).

Eisenbarth, Williams, Colegio, Meng, Strowig, Rongvaux, Henao-Mejia, Thaiss, Joly, Gonzalez, Xu, Zenewicz, Haberman, Elinav, Kleinstein, Sutterwala, Flavell: "NLRP10 is a NOD-like receptor essential to initiate adaptive immunity by dendritic cells." in: Nature, Vol. 484, Issue 7395, pp. 510-3, (2012) (PubMed).

Huggins, Paschalidis, Flower, Perretti, DAcquisto: "Annexin-1-deficient dendritic cells acquire a mature phenotype during differentiation." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 23, Issue 4, pp. 985-96, (2009) (PubMed).

Details zu CCR7

Target: CCR7 (Chemokine (C-C Motif) Receptor 7 (CCR7))

Andere Bezeichnung: CD197

Hintergrund: Chemokine (C-C motif) receptor 7,CD197 / CCR7 (chemokine receptor 7) is a seven membrane-spanning protein serving as a receptor for chemokines CCL19 and CCL21. It is expressed on most naive T cells, some hematopoietic stem cells, mature dendritic cells, NK cells and some memory T cells and B cells subsets. CD197 plays important roles in development of thymocytes, and regulating the recirculation and homing of lymphocytes and dendritic cells to secondary lymphoid organs.,CCR7, CC-CKR-7, EBI1

Gen-ID: 12775

UniProt: P47774

Pathways: Regulation of Actin Filament Polymerization, Positive Regulation of Immune Effector Process