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PKC mu Antikörper (Ser738)

Der Kaninchen Polyklonal Anti-PKC mu-Antikörper wurde für WB und IF validiert. Er ist geeignet, PKC mu in Proben von Human, Maus und Ratte zu detektieren.
Produktnummer ABIN197312

Kurzübersicht für PKC mu Antikörper (Ser738) (ABIN197312)

Target

Alle PKC mu (PRKD1) Antikörper anzeigen
PKC mu (PRKD1) (Protein Kinase D1 (PRKD1))

Reaktivität

  • 122
  • 76
  • 66
  • 4
  • 3
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
Human, Maus, Ratte

Wirt

  • 134
  • 2
  • 2
Kaninchen

Klonalität

  • 128
  • 10
Polyklonal

Konjugat

  • 67
  • 8
  • 5
  • 5
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 1
  • 1
Dieser PKC mu Antikörper ist unkonjugiert

Applikation

  • 96
  • 50
  • 40
  • 40
  • 31
  • 16
  • 13
  • 10
  • 4
  • 3
  • 1
Western Blotting (WB), Immunofluorescence (IF)
  • Bindungsspezifität

    • 19
    • 16
    • 15
    • 15
    • 12
    • 8
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Ser738

    Spezifität

    This antibody detects endogenous levels of total PKD/PKCμ protein.

    Aufreinigung

    Immunoaffinity Chromatography using epitope-specific immunogen.

    Immunogen

    The antiserum was produced against synthesized non-phosphopeptide derived from human PKD/PKCmy around the phosphorylation site of serine 738 (E-K-Sp-F-R).
  • Applikationshinweise

    Western blot: 1/500-1/1000. Immunofluorescence: 1/100-1/200.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Konzentration

    1.0 mg/mL

    Buffer

    PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % Sodium Azide and 50 % Glycerol.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Handhabung

    Avoid repeated freezing and thawing.

    Lagerung

    -20 °C

    Informationen zur Lagerung

    Store the antibody (in aliquots) at -20 °C.
  • Target

    PKC mu (PRKD1) (Protein Kinase D1 (PRKD1))

    Andere Bezeichnung

    PRKD1

    Hintergrund

    Protein Kinase C mu, is a ~140 kDa member of the novel group (nPKCs: sensitive to diacylglycerol, phosphatidylserine, and phorbol esters) of the PKC family of serine/threonine kinases that are involved in a wide range of physiological processes including mitogenesis, cell survival, metastasis and transcriptional regulation. PKC mu (also known as Protein Kinase D or PKD) is implicated in the regulation of multiple cellular processes including Golgi organization and membrane transport in epithelial cells. PKC mu is phosphorylated on serine 742 (serine 748 for the mouse sequence) in the activation loop in a PKC-dependent pathway, mainly by PKC eta and PKC epsilon. This is critical for its catalytic activity, substrate phosphorylation and role in activating the ERK1 MAP Kinase signaling cascade.Synonyms: PKC D1, PKC mu, PKD, PKD1, PRKCM, Protein kinase C mu type, Protein kinase D, Serine/threonine-protein kinase D1, nPKC-D1, nPKC-mu

    Gen-ID

    5587

    NCBI Accession

    NP_002733

    UniProt

    Q15139

    Pathways

    Myometrial Relaxation and Contraction
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