RGS10 Antikörper

Produktnummer ABIN1944932

Der Kaninchen Polyklonal Anti-RGS10-Antikörper wurde für WB validiert. Er ist geeignet, RGS10 in Proben von Human, Ratte und Maus zu detektieren. Es sind 3+ Publikationen verfügbar.

Kurzübersicht für RGS10 Antikörper (ABIN1944932)

Target: RGS10 (Regulator of G-Protein Signaling 10 (RGS10))

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RGS10 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-RGS10 Antikörper

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Lagerung: 4 °C,-20 °C

Referenzen für anti-RGS10 Antikörper (ABIN1944932)

Burgon, Lee, Nixon, Peralta, Casey: "Phosphorylation and nuclear translocation of a regulator of G protein signaling (RGS10)." in: The Journal of biological chemistry, Vol. 276, Issue 35, pp. 32828-34, (2001) (PubMed).

Chatterjee, Fisher: "Cytoplasmic, nuclear, and golgi localization of RGS proteins. Evidence for N-terminal and RGS domain sequences as intracellular targeting motifs." in: The Journal of biological chemistry, Vol. 275, Issue 31, pp. 24013-21, (2000) (PubMed).

Hunt, Fields, Casey, Peralta: "RGS10 is a selective activator of G alpha i GTPase activity." in: Nature, Vol. 383, Issue 6596, pp. 175-7, (1996) (PubMed).

Details zu RGS10

Target: RGS10 (Regulator of G-Protein Signaling 10 (RGS10))

Andere Bezeichnung: RGS10

Hintergrund: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Associates specifically with the activated forms of the G protein subunits G(i)-alpha and G(z)- alpha but fails to interact with the structurally and functionally distinct G(s)-alpha subunit. Activity on G(z)-alpha is inhibited by palmitoylation of the G-protein.

Molekulargewicht: 20236 Da

Gen-ID: 6001

UniProt: O43665

Pathways: Myometrial Relaxation and Contraction, Regulation of G-Protein Coupled Receptor Protein Signaling