FA13A (Cleaved-Gly39) Antikörper

Produktnummer ABIN1944829

Produktdetails

Target: FA13A

Bindungsspezifität: Cleaved-Gly39

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Unkonjugiert

Applikation: Western Blotting (WB)

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: WB: 1:500- 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Lagerung: 4 °C,-20 °C

Referenzen

Ichinose, Davie: "Characterization of the gene for the a subunit of human factor XIII (plasma transglutaminase), a blood coagulation factor." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 85, Issue 16, pp. 5829-33, (1988) (PubMed).

Ichinose, Hendrickson, Fujikawa, Davie: "Amino acid sequence of the a subunit of human factor XIII." in: Biochemistry, Vol. 25, Issue 22, pp. 6900-6, (1987) (PubMed).

Grundmann, Amann, Zettlmeissl, Küpper: "Characterization of cDNA coding for human factor XIIIa." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 83, Issue 21, pp. 8024-8, (1986) (PubMed).

Antigendetails

Target: FA13A

Hintergrund: Factor XIII is activated by thrombin and calcium ion to a transglutaminase that catalyzes the formation of gamma-glutamyl- epsilon-lysine cross-links between fibrin chains, thus stabilizing the fibrin clot. Also cross-link alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin.

Molekulargewicht: 83267 Da

Gen-ID: 2162

UniProt: P00488