PAR1 Antikörper

Produktnummer ABIN1944818

Es sind 3+ Publikationen für dieses Produkt verfügbar. Der Kaninchen Polyklonal anti-PAR1 Antikörper wird verwendet zum Nachweis von PAR1 in Proben von Human. Er wurde validiert für WB.

Kurzübersicht für PAR1 Antikörper (ABIN1944818)

Target: PAR1 (F2R) (Coagulation Factor II (thrombin) Receptor (F2R))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PAR1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-PAR1 Antikörper

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: WB: 1:500- 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Lagerung: 4 °C,-20 °C

Referenzen für anti-PAR1 Antikörper (ABIN1944818)

Zania, Gourni, Aplin, Nicosia, Flordellis, Maragoudakis, Tsopanoglou: "Parstatin, the cleaved peptide on proteinase-activated receptor 1 activation, is a potent inhibitor of angiogenesis." in: The Journal of pharmacology and experimental therapeutics, Vol. 328, Issue 2, pp. 378-89, (2009) (PubMed).

Kahn, Nakanishi-Matsui, Shapiro, Ishihara, Coughlin: "Protease-activated receptors 1 and 4 mediate activation of human platelets by thrombin." in: The Journal of clinical investigation, Vol. 103, Issue 6, pp. 879-87, (1999) (PubMed).

Shapiro, Trejo, Zeng, Coughlin: "Role of the thrombin receptor's cytoplasmic tail in intracellular trafficking. Distinct determinants for agonist-triggered versus tonic internalization and intracellular localization." in: The Journal of biological chemistry, Vol. 271, Issue 51, pp. 32874-80, (1997) (PubMed).

Details zu PAR1

Target: PAR1 (F2R) (Coagulation Factor II (thrombin) Receptor (F2R))

Andere Bezeichnung: Thrombin Receptor

Hintergrund: High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation and in vascular development.

Molekulargewicht: 47441 Da

Gen-ID: 2149

UniProt: P25116

Pathways: Nuclear Receptor Transcription Pathway, Skeletal Muscle Fiber Development, Positive Regulation of Endopeptidase Activity, Protein targeting to Nucleus