Thrombomodulin Antikörper

Produktnummer ABIN1944809

Der Kaninchen Polyklonal Anti-Thrombomodulin-Antikörper wurde für WB validiert. Er ist geeignet, Thrombomodulin in Proben von Human zu detektieren. Es sind 5+ Publikationen verfügbar.

Kurzübersicht für Thrombomodulin Antikörper (ABIN1944809)

Target: Thrombomodulin (THBD)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Thrombomodulin Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-Thrombomodulin Antikörper

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Lagerung: 4 °C,-20 °C

Referenzen für anti-Thrombomodulin Antikörper (ABIN1944809)

Deloukas, Matthews, Ashurst, Burton, Gilbert, Jones, Stavrides, Almeida, Babbage, Bagguley, Bailey, Barlow, Bates, Beard, Beare, Beasley, Bird, Blakey, Bridgeman, Brown, Buck, Burrill, Butler, Carder et al.: "The DNA sequence and comparative analysis of human chromosome 20. ..." in: Nature, Vol. 414, Issue 6866, pp. 865-71, (2002) (PubMed).

Shirai, Shiojiri, Ito, Yamamoto, Kusumoto, Deyashiki, Maruyama, Suzuki: "Gene structure of human thrombomodulin, a cofactor for thrombin-catalyzed activation of protein C." in: Journal of biochemistry, Vol. 103, Issue 2, pp. 281-5, (1988) (PubMed).

Suzuki, Kusumoto, Deyashiki, Nishioka, Maruyama, Zushi, Kawahara, Honda, Yamamoto, Horiguchi: "Structure and expression of human thrombomodulin, a thrombin receptor on endothelium acting as a cofactor for protein C activation." in: The EMBO journal, Vol. 6, Issue 7, pp. 1891-7, (1987) (PubMed).

Jackman, Beeler, Fritze, Soff, Rosenberg: "Human thrombomodulin gene is intron depleted: nucleic acid sequences of the cDNA and gene predict protein structure and suggest sites of regulatory control." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 84, Issue 18, pp. 6425-9, (1987) (PubMed).

Wen, Dittman, Ye, Deaven, Majerus, Sadler: "Human thrombomodulin: complete cDNA sequence and chromosome localization of the gene." in: Biochemistry, Vol. 26, Issue 14, pp. 4350-7, (1987) (PubMed).

Details zu Thrombomodulin

Target: Thrombomodulin (THBD)

Andere Bezeichnung: THBD

Hintergrund: Thrombomodulin is a specific endothelial cell receptor that forms a 1:1 stoichiometric complex with thrombin. This complex is responsible for the conversion of protein C to the activated protein C (protein Ca). Once evolved, protein Ca scissions the activated cofactors of the coagulation mechanism, factor Va and factor VIIIa, and thereby reduces the amount of thrombin generated.

Molekulargewicht: 60329 Da

Gen-ID: 7056

UniProt: P07204