MAGED1 Antikörper (AA 20-224)

Produktnummer ABIN1944790

Dieser Maus Monoklonal Antikörper detektiert spezifisch MAGED1 in WB. Es zeigt Reaktivität gegenüber Proben von Human. Es wurde in 3+ Publikationen zitiert.

Kurzübersicht für MAGED1 Antikörper (AA 20-224) (ABIN1944790)

Target: MAGED1 (Melanoma Antigen Family D, 1 (MAGED1))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser MAGED1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: 1305CT862-157-127

Produktdetails anti-MAGED1 Antikörper

Bindungsspezifität: AA 20-224

Aufreinigung: This antibody is purified through a protein G column, followed by dialysis against PBS.

Immunogen: This MAGED1 antibody is generated from a mouse immunized with a KLH conjugated synthetic peptide between 20-224 amino acids from the Central region of human MAGED1.

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise: WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Referenzen für anti-MAGED1 Antikörper (ABIN1944790)

Wen, Xue, Qin, Yu, Zhang, Zhao, Gao, Gu, Li: "hNRAGE, a human neurotrophin receptor interacting MAGE homologue, regulates p53 transcriptional activity and inhibits cell proliferation." in: FEBS letters, Vol. 564, Issue 1-2, pp. 171-6, (2004) (PubMed).

Salehi, Roux, Kubu, Zeindler, Bhakar, Tannis, Verdi, Barker: "NRAGE, a novel MAGE protein, interacts with the p75 neurotrophin receptor and facilitates nerve growth factor-dependent apoptosis." in: Neuron, Vol. 27, Issue 2, pp. 279-88, (2000) (PubMed).

Põld, Zhou, Chen, Hall, Vescio, Berenson: "Identification of a new, unorthodox member of the MAGE gene family." in: Genomics, Vol. 59, Issue 2, pp. 161-7, (1999) (PubMed).

Details zu MAGED1

Target: MAGED1 (Melanoma Antigen Family D, 1 (MAGED1))

Andere Bezeichnung: MAGED1

Hintergrund: Involved in the apoptotic response after nerve growth factor (NGF) binding in neuronal cells. Binds NGFR/p75NTR and antagonizes its association with NTRK1/TrkA, inhibits cell cycle progression, and facilitates NGFR-mediated apoptosis. May act as a regulator of the function of DLX family members. May regulate TP53/p53 transcriptional activity and inhibit cell proliferation. Enhances TP53 phosphorylation and accumulation. May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex.

Molekulargewicht: 86161

Gen-ID: 9500

UniProt: Q9Y5V3

Pathways: Neurotrophin Signalübertragung