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Endoglin Antikörper (APC)

Name: Endoglin Antikörper (APC)
Brand: antibodies-online
SKU: ABIN192217
Price: 544.67 EUR
Availability: InStock

ENG Reaktivität: Human, Ratte FACS Wirt: Maus Monoclonal MEM-226 APC

Separation of HUVEC cells stained using anti-human CD105 (MEM-226) APC antibody (10 μL reagent per million cells in 100 μL of cell suspension, red-filled) from HUVEC cells stained using mouse IgG2a isotype control (MOPC-173) APC antibody (concentration in sample 1 μg/mL, same as CD105 APC concentration, black-dashed) in flow cytometry analysis (surface staining) of HUVEC cell suspension. (Endoglin Antikörper (APC))

FACS

Surface staining (mass cytometry) of hTERT cell line with anti-human CD105 () 143Nd. (Endoglin Antikörper (APC))

FACS

Surface staining (flow cytometry) of HUVEC (human umbilical vein endothelial cells) with anti-human CD105 (MEM-226) FITC. (Endoglin Antikörper (APC))

FACS

Surface staining of HUVEC (human umbilical vein endothelial cells) with anti-CD105 (MEM-226) APC. (Endoglin Antikörper (APC))

FACS

4 Abbildungen

(1 reference)

Produktnummer ABIN192217

Datenblatt (PDF)

Target Alle Endoglin (ENG) Antikörper anzeigen

Endoglin (ENG)
Reaktivität
171

65

44

16

7

5

4

3

3

3

1
Human, Ratte
Wirt
114

75

21

1
Maus
Passende Sekundärantikörper
Klonalität
110

100

1
Monoklonal
Konjugat
92

23

20

20

10

7

3

3

2

2

2

2

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1
Dieser Endoglin Antikörper ist konjugiert mit APC
Applikation
134

130

60

50

34

24

24

20

16

14

13

7

6

3

3

2

2

2

2

1

1

1

1

1

1

1
Flow Cytometry (FACS)

Verwendungszweck

Anti-Hu CD105 APC

Spezifität

The antibody MEM-226 reacts with an extracellular epitope of CD105 (Endoglin), a 90 kDa type I homodimerizing membrane glycoprotein expressed on vascular endothelial cells (small and large vessels), activated monocytes and tissue macrophages, stromal cells of certain tissues including bone marrow, pre-B lymphocytes in fetal marrow and erythroid precursors in fetal and adult bone marrow, it is also present on syncytiotrophoblast on placenta throughout pregnancy.

Kreuzreaktivität (Details)

Human, Rat

Aufreinigung

Purified antibody is conjugated with activated allophycocyanin (APC) under optimum conditions and unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.

Immunogen

Recombinant Vaccinia virus containing the human CD105 cDNA.

Klon

MEM-226

Isotyp

IgG2a

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Applikationshinweise

Flow cytometry: The reagent is designed for analysis of human blood cells using 10 μL reagent / 100 μL of whole blood or 10⁶ cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests.

Beschränkungen

Nur für Forschungszwecke einsetzbar
Rekonstitution

No reconstitution is necessary.

Buffer

Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Konservierungsmittel

Sodium azide

Vorsichtsmaßnahmen

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung

Do not freeze.
Avoid prolonged exposure to light.

Lagerung

4 °C

Informationen zur Lagerung

Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
Schmidt, Achermann, Odermatt, Breymann, Mol, Genoni, Zund, Hoerstrup: "Prenatally fabricated autologous human living heart valves based on amniotic fluid derived progenitor cells as single cell source." in: Circulation, Vol. 116, Issue 11 Suppl, pp. I64-70, (2007) (PubMed).
Target

Endoglin (ENG)

Andere Bezeichnung

CD105 (ENG Produkte)

Hintergrund

Endoglin,CD105 (endoglin) is a homodimeric transmembrane glycoprotein serving in presence of TGFbetaR-2 as a receptor for TGFbeta-1 and TGFbeta-3. CD105 is highly expressed on endothelial cells and promotes angiogenesis during wound healing, infarcts and in a wide range of tumours and its gene expression is stimulated by hypoxia. CD105 prevents apoptosis in hypoxic endothelial cells and also antagonises the inhibitory effects of TGFbeta-1 on vascular endothelial cell growth and migration. Normal cellular levels of CD105 are required for formation of new blood vessels.,Endoglin, END, ENG, HHT1, ORW1

Gen-ID

2022

UniProt

P17813