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Endoglin Antikörper (APC)

Dieses Maus Monoklonal-Antikörper erkennt spezifisch Endoglin in FACS. Er zeigt eine Reaktivität gegenüber Human und Ratte und wurde in 1 Publikation erwähnt.
Produktnummer ABIN192217

Kurzübersicht für Endoglin Antikörper (APC) (ABIN192217)

Target

Alle Endoglin (ENG) Antikörper anzeigen
Endoglin (ENG)

Reaktivität

  • 216
  • 71
  • 71
  • 20
  • 19
  • 16
  • 15
  • 3
  • 3
  • 3
  • 2
  • 1
Human, Ratte

Wirt

  • 133
  • 118
  • 21
  • 3
  • 2
  • 1
Maus

Klonalität

  • 151
  • 126
  • 1
Monoklonal

Konjugat

  • 120
  • 31
  • 28
  • 24
  • 14
  • 7
  • 3
  • 3
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser Endoglin Antikörper ist konjugiert mit APC

Applikation

  • 165
  • 159
  • 90
  • 55
  • 49
  • 33
  • 29
  • 25
  • 25
  • 18
  • 13
  • 10
  • 7
  • 6
  • 5
  • 4
  • 3
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Flow Cytometry (FACS)

Klon

MEM-226
  • Verwendungszweck

    Anti-Hu CD105 APC

    Spezifität

    The antibody MEM-226 reacts with an extracellular epitope of CD105 (Endoglin), a 90 kDa type I homodimerizing membrane glycoprotein expressed on vascular endothelial cells (small and large vessels), activated monocytes and tissue macrophages, stromal cells of certain tissues including bone marrow, pre-B lymphocytes in fetal marrow and erythroid precursors in fetal and adult bone marrow, it is also present on syncytiotrophoblast on placenta throughout pregnancy.

    Kreuzreaktivität (Details)

    Human, Rat

    Aufreinigung

    Purified antibody is conjugated with activated allophycocyanin (APC) under optimum conditions and unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.

    Immunogen

    Recombinant Vaccinia virus containing the human CD105 cDNA.

    Isotyp

    IgG2a
  • Applikationshinweise

    Flow cytometry: The reagent is designed for analysis of human blood cells using 10 μL reagent / 100 μL of whole blood or 106 cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests.

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Rekonstitution

    No reconstitution is necessary.

    Buffer

    Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Handhabung

    Do not freeze.
    Avoid prolonged exposure to light.

    Lagerung

    4 °C

    Informationen zur Lagerung

    Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
  • Schmidt, Achermann, Odermatt, Breymann, Mol, Genoni, Zund, Hoerstrup: "Prenatally fabricated autologous human living heart valves based on amniotic fluid derived progenitor cells as single cell source." in: Circulation, Vol. 116, Issue 11 Suppl, pp. I64-70, (2007) (PubMed).

  • Target

    Endoglin (ENG)

    Andere Bezeichnung

    CD105

    Hintergrund

    Endoglin,CD105 (endoglin) is a homodimeric transmembrane glycoprotein serving in presence of TGFbetaR-2 as a receptor for TGFbeta-1 and TGFbeta-3. CD105 is highly expressed on endothelial cells and promotes angiogenesis during wound healing, infarcts and in a wide range of tumours and its gene expression is stimulated by hypoxia. CD105 prevents apoptosis in hypoxic endothelial cells and also antagonises the inhibitory effects of TGFbeta-1 on vascular endothelial cell growth and migration. Normal cellular levels of CD105 are required for formation of new blood vessels.,Endoglin, END, ENG, HHT1, ORW1

    Gen-ID

    2022

    UniProt

    P17813
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