HSP70 Antikörper

Produktnummer ABIN191986

Produktdetails anti-HSP70 Antikörper

Target: HSP70 (Heat Shock Protein 70 (HSP70))

Reaktivität: Geodia cydonium

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser HSP70 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Frozen Sections) (IHC (fro)), Enzyme Immunoassay (EIA)

Spezifität: This antibody detects HSP70.

Produktmerkmale: Synonyms: Heat Shock Protein 70

Aufreinigung: Protein G chromatography

Immunogen: HSP70 from Geodia cydonium

Klon: IVF5

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: ELISA: 1: 5,000. Western blot: 1: 500. Immunoprecipitation: 1: 50. Immunohistochemistry: 1: 50.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Rekonstitution: Restore in aqua bidest to 1 mg/mL.

Buffer: 50 mM TRIS pH 7.4

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store lyophilized at 2 - 8 °C and reconstituted at -20 °C. Avoid repeated freezing andthawing.
Shelf life: One year from despatch.

Haltbarkeit: 12 months

Details zu HSP70

Target: HSP70 (Heat Shock Protein 70 (HSP70))

Andere Bezeichnung: Hsp70 (HSP70 Produkte)

Hintergrund: Heat shock proteins (HSPs) or stress response proteins (SRPs) are synthesized in variety of environmental and pathophysiological stressful conditions. Many HSPs are involved in processes such as protein denaturation-renaturation, folding-unfolding, transport-translocation, activation-inactivation, and secretion. HSP70 is found to be associated with steroid receptors, actin, p53, polyoma T antigen, nucleotides, and other unknown proteins. Also, HSP70 has been shown to be involved in protective roles against thermal stress, cytotoxic drugs, and other damaging conditions. Heat shock proteins are produced by prokaryotic and eukaryotic cells, and are among the most conserved molecules in phylogeny. Eukaryotic cells contain an HSP70 multigene that differ in their intracellular location and regulation. Members of the HSP70 family play a major role in the folding, unfolding and translocation of polypeptides as well as in the assembly and disassembly of oligomeric protein complexes, as well as in the immune response. HSP72 was found to increase dramatically in the brains of Alzheimer's disease patients, and was localized exclusively in neuritic plaques and neurofibrillary tangles. HSP70 concentrates in nuclei during heat shock and returns to the cytoplasm when the shock is removed.Synonyms: Heat Shock Protein 70

UniProt: Q24952