Caspase 12 (Small) Antikörper

Produktnummer ABIN1888251

Der Kaninchen Polyklonal anti-Caspase 12 (Small) Antikörper (ABIN1888251) detektiert spezifisch Caspase 12 (Small) in IHC, ELISA und WB. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Maus und Ratte.

Kurzübersicht für Caspase 12 (Small) Antikörper (ABIN1888251)

Target: Caspase 12 (Small)

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Applikation: Immunohistochemistry (IHC), ELISA, Western Blotting (WB)

Produktdetails

Aufreinigung: Affinity chromatography purified via peptide column

Immunogen: Synthetic peptide corresponding to amino acids within the small cleavage product of murine caspase-12.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Handhabung: Avoid freezing and thawing repeatly.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Antigendetails

Target: Caspase 12 (Small)

Hintergrund: Three distinct signaling pathways lead to programmed cell death (apoptosis).The death receptor and mitochondrion pathways are the main, in which the key apoptotic proteases capase-8 and caspase-9, respectively, are involved.The endoplasmic reticulum (ER) stress is the third apoptotic pathway and caspase-12 is involved.Caspase-12 is localized to the ER but not to cytoplasm or mitochondrion.Caspase-12 is activated by ER stress, including disruption of ER calcium homeostasis, and mediates ER stress-induced apoptosis.Caspase-12 is co-localized to the ER with several proteins that are involved in Alzheimer's disease including gamma-secretase presenilin and beta-amyloid precursor protein (APP).Caspase-12 mediates cytotoxicity induced by amyloid-beta.Caspase-12 is ubiquitously expressed in mouse tissues.
Synonyms: Caspase-12 (small), Casp-12 (sml)