IRGC Antikörper (N-Term)

Produktnummer ABIN1887842

Der Kaninchen Polyklonal Anti-IRGC-Antikörper wurde für WB, ELISA und ICC validiert. Er ist geeignet, IRGC in Proben von Human, Ratte und Maus zu detektieren.

Kurzübersicht für IRGC Antikörper (N-Term) (ABIN1887842)

Target: IRGC (Immunity-Related GTPase Family, Cinema (IRGC))

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser IRGC Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunocytochemistry (ICC)

Produktdetails anti-IRGC Antikörper

Bindungsspezifität: N-Term

Spezifität: Two isoforms of IRGC are known to exist, this antibody will only recognize the IRGCa isoform.

Aufreinigung: Affinity chromatography purified via peptide column

Immunogen: 13 amino acid peptide near the amino terminus of human IRGC.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Handhabung: Avoid freezing and thawing repeatly.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Details zu IRGC

Target: IRGC (Immunity-Related GTPase Family, Cinema (IRGC))

Andere Bezeichnung: IRGC

Hintergrund: Immunity-related GTPases (IRG) (also known as p47 GTPases) are a family of GTPase proteins found in vertebrates, which play critical roles in mediating innate resistance to intracellular pathogens.IRG genes have been found in a number of mammals and lower species including mice, rats, zebrafish and humans.Most of the mouse genes contain interferon-stimulated response elements which mediate transcriptional activation by IFNs.In humans, only two IRG genes have been found: human IRGC encodes a full-length IRG protein that, like the mouse homologue, is constitutively expressed in testis, while human IRGM encodes a considerably truncated protein that is constitutively expressed in cultured cells including some macrophage cell lines.As the two human genes IRGC and IRGM are not subject to IFN control, it has been suggested that the host resistance mechanism supported by IRG proteins in the mouse is lacking in humans.
Synonyms: Immunity-related GTPase cinema 1, Interferon-inducible GTPase 5, Iigp5, CINEMA

NCBI Accession: NP_062558