GFRA1 Antikörper (AA 369-382)

Produktnummer ABIN1886874

Der Kaninchen Polyklonal anti-GFRA1 Antikörper (ABIN1886874) detektiert spezifisch GFRA1 in WB, IHC und ELISA. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Maus und Ratte.

Kurzübersicht für GFRA1 Antikörper (AA 369-382) (ABIN1886874)

Target: GFRA1 (GDNF Family Receptor alpha 1 (GFRA1))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GFRA1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Produktdetails anti-GFRA1 Antikörper

Bindungsspezifität: AA 369-382

Spezifität: The amino acid sequence of immunogenic peptide is identical to those of mouse and rat and the antibody recognizes GFR alpha 1 from human, mouse and rat origins.

Aufreinigung: Purified by DEAE column

Immunogen: Peptide corresponding to amino acids 369 to 382 of human GFR alpha 1.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Handhabung: Avoid freezing and thawing repeatly.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Details zu GFRA1

Target: GFRA1 (GDNF Family Receptor alpha 1 (GFRA1))

Andere Bezeichnung: GFR alpha 1

Hintergrund: Glial cell line-derived neurotrophic factor (GDNF) is a potent survival factor for central and peripheral neurons and is essential for the development of kidneys and the enteric nerves system.Physiological responses to GDNF require the presence of a novel glycosylphosphadidylinositol linked protein GDNFRalpha, which is a cell surface receptor for GDNF.The cDNAs encoding GDNFRalpha from human, rat, chicken and mouse have been cloned recently.GDNFRalpha was also termed Ret ligand 1 (RETL1) or TGF-beta-related neurotrophic factor receptor 1 (TrnR1) and nominated as GFRalpha-1 recently.GFRalpha-1 binds GDNF specifically and mediates activation of the Ret protein tyrosine kinase (PTK).Thus, GDNF, GFRalpha and the Ret PTK form a complex to transduce GDNF signal and to mediate GDNF function.
Synonyms: GFR alpha 1, GFRa-1, GDNFRa, GDNFRalpha

UniProt: P56159