Cofilin 2 Antikörper (AA 92-152)

Produktnummer ABIN1886714

Der Kaninchen Polyklonal Anti-Cofilin 2-Antikörper wurde für WB, IHC und IF validiert. Er ist geeignet, Cofilin 2 in Proben von Human zu detektieren.

Kurzübersicht für Cofilin 2 Antikörper (AA 92-152) (ABIN1886714)

Target: Cofilin 2 (CFL2)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Cofilin 2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Produktdetails anti-Cofilin 2 Antikörper

Bindungsspezifität: AA 92-152

Aufreinigung: Purified by antigen-affinity chromatography.

Immunogen: Synthetic peptide contain a sequence corresponding to a region within amino acids 92 and 152 of Cofilin 2

Anwendungsinformationen

Applikationshinweise: Suggested dilutions:
Western blotting: 1.500-1.3000
Immunohistochemistry: 1.100-1.250
Immunofluorescence: 1.100-1.200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: 1 x PBS, 1 % BSA, 20 % Glycerol (pH 7.0).0.01 % Thimerosal was added as a preservative.

Konservierungsmittel: Thimerosal (Merthiolate)

Vorsichtsmaßnahmen: Biohazard Informations: This product contains thimerosal which is hazardous.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.

Details zu Cofilin 2

Target: Cofilin 2 (CFL2)

Andere Bezeichnung: Cofilin 2

Hintergrund: Cofilin is a widely distributed intracellular actin-modulating protein that binds and depolymerizes filamentous F-actin and inhibits the polymerization of monomeric G-actin in a pH-dependent manner.(Gillett et al., 1996 [PubMed 8800436]).Cofilin-2 is a member of the AC group of proteins that also includes cofilin-1 (CFL1) and destrin (DSTN, MIM 609114), all of which regulate actin-filament dynamics (Bamburg et al., 1999 [PubMed 10461190], Maciver and Hussey, 2002).The CFL2 gene encodes a skeletal muscle-specific isoform (Vartiainen et al., 2002 [PubMed 11809832]) localized to the thin filaments, where it exerts its effect on actin, in part through interactions with tropomyosins (Ono and Ono, 2002 [PubMed 11901171]).[supplied by OMIM]
Synonyms: NEM7

Molekulargewicht: 19 kDa

Gen-ID: 1073

NCBI Accession: NP_619579, NM_138638

Pathways: Caspase Kaskade in der Apoptose