Suggested dilutions: Western blotting: 1.500-1.3000 Immunohistochemistry: 1.100-1.250 Immunofluorescence: 1.100-1.200
Beschränkungen
Nur für Forschungszwecke einsetzbar
Format
Liquid
Buffer
1 x PBS, 1 % BSA, 20 % Glycerol (pH 7.0).0.01 % Thimerosal was added as a preservative.
Konservierungsmittel
Thimerosal (Merthiolate)
Vorsichtsmaßnahmen
Biohazard Informations: This product contains thimerosal which is hazardous.
Lagerung
4 °C/-20 °C
Informationen zur Lagerung
Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
Target
POLG
(Polymerase (DNA Directed), gamma (POLG))
Andere Bezeichnung
DNA Polymerase gamma
Hintergrund
Mitochondrial DNA polymerase is heterotrimeric, consisting of a homodimer of accessory subunits plus a catalytic subunit.The protein encoded by this gene is the catalytic subunit of mitochondrial DNA polymerase.The encoded protein contains a polyglutamine tract near its N-terminus that may be polymorphic.Defects in this gene are a cause of progressive external ophthalmoplegia with mitochondrial DNA deletions 1 (PEOA1), sensory ataxic neuropathy dysarthria and ophthalmoparesis (SANDO), Alpers-Huttenlocher syndrome (AHS), and mitochondrial neurogastrointestinal encephalopathy syndrome (MNGIE).Two transcript variants encoding the same protein have been found for this gene.[provided by RefSeq]