UNC13(C. Elegans)-Like (AA 680-927) Antikörper

Produktnummer ABIN1886614

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch UNC13(C. Elegans)-Like in IHC, WB und IF. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für UNC13(C. Elegans)-Like (AA 680-927) Antikörper (ABIN1886614)

Target: UNC13(C. Elegans)-Like

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Unkonjugiert

Applikation: Immunohistochemistry (IHC), Western Blotting (WB), Immunofluorescence (IF)

Produktdetails

Bindungsspezifität: AA 680-927

Aufreinigung: Purified by antigen-affinity chromatography.

Immunogen: Recombinant protein fragment contain a sequence corresponding to a region within amino acids 680 and 927 of human UNC13B

Anwendungsinformationen

Applikationshinweise: Suggested dilutions:
Western blotting: 1.500-1.3000
Immunohistochemistry: 1.50-1.500
Immunofluorescence: 1.100-1.200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: 0.1 M Tris-buffered saline with 10 % Glycerol (pH 7.0).0.01 % Thimerosal was added as a preservative.

Konservierungsmittel: Thimerosal (Merthiolate)

Vorsichtsmaßnahmen: Biohazard Informations: This product contains thimerosal which is hazardous.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.

Antigendetails

Target: UNC13(C. Elegans)-Like

Hintergrund: This gene is expressed in the kidney cortical epithelial cells and is upregulated by hyperglycemia.The encoded protein shares a high level of similarity to the rat homolog, and contains 3 C2 domains and a diacylglycerol-binding C1 domain.Hyperglycemia increases the levels of diacylglycerol, which has been shown to induce apoptosis in cells transfected with this gene and thus contribute to the renal cell complications of hyperglycemia.Studies in other species also indicate a role for this protein in the priming step of synaptic vesicle exocytosis.[provided by RefSeq]

Molekulargewicht: 181 kDa

Gen-ID: 10497

NCBI Accession: NP_006368, NM_006377