FGD4 Antikörper (AA 49-297)

Produktnummer ABIN1886512

Produktdetails anti-FGD4 Antikörper

Target: FGD4 (FYVE, RhoGEF and PH Domain Containing 4 (FGD4))

Bindungsspezifität: AA 49-297

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FGD4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (IHC)

Aufreinigung: Purified by antigen-affinity chromatography.

Immunogen: Recombinant protein fragment contain a sequence corresponding to a region within amino acids 49 and 297 of FGD4

Anwendungsinformationen

Applikationshinweise: Suggested dilutions:
Western blotting: 1.500-1.3000
Immunohistochemistry: 1.100-1.500
Immunofluorescence: 1.100-1.200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: 0.1 M Tris-buffered saline with 10 % Glycerol (pH 7.0).0.01 % Thimerosal was added as a preservative.

Konservierungsmittel: Thimerosal (Merthiolate)

Vorsichtsmaßnahmen: Biohazard Informations: This product contains thimerosal which is hazardous.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.

Details zu FGD4

Target: FGD4 (FYVE, RhoGEF and PH Domain Containing 4 (FGD4))

Andere Bezeichnung: FGD4 (FGD4 Produkte)

Synonyme: CMT4H antikoerper, FRABP antikoerper, ZFYVE6 antikoerper, 9030023J02Rik antikoerper, 9330209B17Rik antikoerper, Frabp antikoerper, FYVE, RhoGEF and PH domain containing 4 antikoerper, FGD4 antikoerper, Fgd4 antikoerper

Hintergrund: This gene encodes a protein that is involved in the regulation of the actin cytoskeleton and cell shape.This protein contains an actin filament-binding domain, which together with its Dbl homology domain and one of its pleckstrin homology domains, can form microspikes.This protein can activate MAPK8 independently of the actin filament-binding domain, and it is also involved in the activation of CDC42 via the exchange of bound GDP for free GTP.The activation of CDC42 also enables this protein to play a role in mediating the cellular invasion of Cryptosporidium parvum, an intracellular parasite that infects the gastrointestinal tract.Mutations in this gene can cause Charcot-Marie-Tooth disease type 4H (CMT4H), a disorder of the peripheral nervous system.[provided by RefSeq]

Molekulargewicht: 87 kDa

Gen-ID: 121512

NCBI Accession: NM_139241, NP_640334

Pathways: Neurotrophin Signalübertragung