MC1 Receptor Antikörper (AA 253-317)

Produktnummer ABIN1886268

Der Kaninchen Polyklonal anti-MC1 Receptor Antikörper (ABIN1886268) detektiert spezifisch MC1 Receptor in WB. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für MC1 Receptor Antikörper (AA 253-317) (ABIN1886268)

Target: MC1 Receptor (MC1R) (Melanocortin 1 Receptor (MC1R))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MC1 Receptor Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-MC1 Receptor Antikörper

Bindungsspezifität: AA 253-317

Aufreinigung: Purified by antigen-affinity chromatography.

Immunogen: Synthetic peptide contain a sequence corresponding to a region within amino acids 253 and 317 of Human MC1R

Anwendungsinformationen

Applikationshinweise: Suggested dilutions:
Western blotting: 1.500-1.3000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: 0.1 M Tris-buffered saline with 10 % Glycerol (pH 7.0).0.01 % Thimerosal was added as a preservative.

Konservierungsmittel: Thimerosal (Merthiolate)

Vorsichtsmaßnahmen: Biohazard Informations: This product contains thimerosal which is hazardous.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.

Details zu MC1 Receptor

Target: MC1 Receptor (MC1R) (Melanocortin 1 Receptor (MC1R))

Andere Bezeichnung: MC1-R

Hintergrund: This intronless gene encodes the receptor protein for melanocyte-stimulating hormone (MSH).The encoded protein, a seven pass transmembrane G protein coupled receptor, controls melanogenesis.Two types of melanin exist: red pheomelanin and black eumelanin.Gene mutations that lead to a loss in function are associated with increased pheomelanin production, which leads to lighter skin and hair color.Eumelanin is photoprotective but pheomelanin may contribute to UV-induced skin damage by generating free radicals upon UV radiation.Binding of MSH to its receptor activates the receptor and stimulates eumelanin synthesis.This receptor is a major determining factor in sun sensitivity and is a genetic risk factor for melanoma and non-melanoma skin cancer.Over 30 variant alleles have been identified which correlate with skin and hair color, providing evidence that this gene is an important component in determining normal human pigment variation.[provided by RefSeq]
Synonyms: MSH-R, SHEP2, MGC14337

Molekulargewicht: 35 kDa

Gen-ID: 4157

NCBI Accession: NM_002386, NP_002377

Pathways: cAMP Metabolic Process, Feeding Behaviour