TFIID(SI-1) (AA 158-339) Antikörper

Produktnummer ABIN1886075

Der Kaninchen Polyklonal anti-TFIID(SI-1) Antikörper wird verwendet zum Nachweis von TFIID(SI-1) in Proben von Human. Er wurde validiert für IHC und WB.

Kurzübersicht für TFIID(SI-1) (AA 158-339) Antikörper (ABIN1886075)

Target: TFIID(SI-1)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Applikation: Immunohistochemistry (IHC), Western Blotting (WB)

Produktdetails

Bindungsspezifität: AA 158-339

Aufreinigung: Affinity purified by Protein A.

Immunogen: Recombinant protein fragment contain a sequence corresponding to a region within amino acids 158 and 339 of Human TBP

Anwendungsinformationen

Applikationshinweise: Suggested dilutions:
Western blotting: 1.500-1.3000
Immunohistochemistry: 1.100-1.250

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: 0.1 M Tris-buffered saline with 10 % Glycerol (pH 7.0).0.01 % Thimerosal was added as a preservative.

Konservierungsmittel: Thimerosal (Merthiolate)

Vorsichtsmaßnahmen: Biohazard Informations: This product contains thimerosal which is hazardous.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.

Antigendetails

Target: TFIID(SI-1)

Hintergrund: Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides.The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals.TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs.TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation.This gene encodes TBP, the TATA-binding protein.A distinctive feature of TBP is a long string of glutamines in the N-terminal.This region of the protein modulates the DNA binding activity of the C terminus, and modulation of DNA binding affects the rate of transcription complex formation and initiation of transcription.Mutations that expand the number of CAG repeats encoding this polyglutamine tract, and thus increase the length of the polyglutamine string, are associated with spinocerebellar ataxia 17, a neurodegenerative disorder classified as a polyglutamine disease.[provided by RefSeq]
Synonyms: GTF2D, SCA17, TFIID, GTF2D1, MGC117320, MGC126054, MGC126055

Molekulargewicht: 38 kDa

Gen-ID: 6908

NCBI Accession: NP_003185, NM_003194