ALPL Antikörper (AA 1-369)

Produktnummer ABIN1885918

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch ALPL in WB und IHC. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für ALPL Antikörper (AA 1-369) (ABIN1885918)

Target: ALPL (Alkaline Phosphatase, Liver/bone/kidney (ALPL))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ALPL Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-ALPL Antikörper

Bindungsspezifität: AA 1-369

Aufreinigung: Purified by antigen-affinity chromatography.

Immunogen: Recombinant protein fragment contain a sequence corresponding to a region within amino acids 1 and 369 of alkaline phosphatase (liver/bone/kidney)

Anwendungsinformationen

Applikationshinweise: Suggested dilutions:
Western blotting: 1.500-1.3000
Immunohistochemistry: 1.50-1.500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: 0.1 M Tris-buffered saline with 10 % Glycerol (pH 7.0).0.01 % Thimerosal was added as a preservative.

Konservierungsmittel: Thimerosal (Merthiolate)

Vorsichtsmaßnahmen: Biohazard Informations: This product contains thimerosal which is hazardous.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.

Details zu ALPL

Target: ALPL (Alkaline Phosphatase, Liver/bone/kidney (ALPL))

Andere Bezeichnung: alkaline phosphatase(liver/bone/kidney)

Hintergrund: There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific).The first three are located together on chromosome 2, while the tissue non-specific form is located on chromosome 1.The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme.The exact physiological function of the alkaline phosphatases is not known.A proposed function of this form of the enzyme is matrix mineralization, however, mice that lack a functional form of this enzyme show normal skeletal development.This enzyme has been linked directly to hypophosphatasia, a disorder that is characterized by hypercalcemia and includes skeletal defects.The character of this disorder can vary, however, depending on the specific mutation since this determines age of onset and severity of symptoms.Alternatively spliced transcript variants, which encode the same protein, have been identified for this gene.[provided by RefSeq]

Molekulargewicht: 57 kDa

Gen-ID: 249

NCBI Accession: NM_000478, NP_000469