F13A1 Antikörper (AA 1-228)

Produktnummer ABIN1885812

Dieses Anti-F13A1-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von F13A1 in WB, IHC und IF. Geeignet für Human.

Kurzübersicht für F13A1 Antikörper (AA 1-228) (ABIN1885812)

Target: F13A1 (Coagulation Factor XIII, A1 Polypeptide (F13A1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser F13A1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Produktdetails anti-F13A1 Antikörper

Bindungsspezifität: AA 1-228

Aufreinigung: Purified by antigen-affinity chromatography.

Immunogen: Recombinant protein fragment contain a sequence corresponding to a region within amino acids 1 and 228 of Factor XIIIa

Anwendungsinformationen

Applikationshinweise: Suggested dilutions:
Western blotting: 1.500-1.3000
Immunohistochemistry: 1.100-1.500
Immunofluorescence: 1.100-1.200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: 0.1 M Tris-buffered saline with 10 % Glycerol (pH 7.0).0.01 % Thimerosal was added as a preservative.

Konservierungsmittel: Thimerosal (Merthiolate)

Vorsichtsmaßnahmen: Biohazard Informations: This product contains thimerosal which is hazardous.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.

Details zu F13A1

Target: F13A1 (Coagulation Factor XIII, A1 Polypeptide (F13A1))

Andere Bezeichnung: Factor XIIIa

Hintergrund: This gene encodes the coagulation factor XIII A subunit.Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade.Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits.The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as plasma carrier molecules.Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin.Upon cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII.This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot.It also crosslinks alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin.Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits, and type II deficiency, characterized by the lack of the A subunit alone.These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion.[provided by RefSeq]

Molekulargewicht: 83 kDa

Gen-ID: 2162

NCBI Accession: NP_000120, NM_000129