FKBP4 Antikörper (AA 1-177)

Produktnummer ABIN1885705

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch FKBP4 in WB, IHC und IF. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für FKBP4 Antikörper (AA 1-177) (ABIN1885705)

Target: FKBP4 (FK506 Binding Protein 4, 59kDa (FKBP4))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FKBP4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Produktdetails anti-FKBP4 Antikörper

Bindungsspezifität: AA 1-177

Aufreinigung: Purified by antigen-affinity chromatography.

Immunogen: Recombinant protein fragment contain a sequence corresponding to a region within amino acids 1 and 177 of FKBP52

Anwendungsinformationen

Applikationshinweise: Suggested dilutions:
Western blotting: 1.500-1.3000
Immunohistochemistry: 1.100-1.500
Immunofluorescence: 1.100-1.200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: 0.1 M Tris-buffered saline with 20 % Glycerol (pH 7.0).0.01 % Thimerosal was added as a preservative.

Konservierungsmittel: Thimerosal (Merthiolate)

Vorsichtsmaßnahmen: Biohazard Informations: This product contains thimerosal which is hazardous.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.

Details zu FKBP4

Target: FKBP4 (FK506 Binding Protein 4, 59kDa (FKBP4))

Andere Bezeichnung: FKBP52

Hintergrund: The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking.This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin.It has high structural and functional similarity to FK506-binding protein 1A (FKBP1A), but unlike FKBP1A, this protein does not have immunosuppressant activity when complexed with FK506.It interacts with interferon regulatory factor-4 and plays an important role in immunoregulatory gene expression in B and T lymphocytes.This encoded protein is known to associate with phytanoyl-CoA alpha-hydroxylase.It can also associate with two heat shock proteins (hsp90 and hsp70) and thus may play a role in the intracellular trafficking of hetero-oligomeric forms of the steroid hormone receptors.This protein correlates strongly with adeno-associated virus type 2 vectors (AAV) resulting in a significant increase in AAV-mediated transgene expression in human cell lines.Thus this encoded protein is thought to have important implications for the optimal use of AAV vectors in human gene therapy.The human genome contains several non-transcribed pseudogenes similar to this gene.[provided by RefSeq]

Molekulargewicht: 52 kDa

Gen-ID: 2288

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway