IL-33 Antikörper

Produktnummer ABIN1885548

Dieses Anti-IL-33-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von IL-33 in WB, ELISA und IHC. Geeignet für Human und Maus.

Kurzübersicht für IL-33 Antikörper (ABIN1885548)

Target: IL-33 (IL33) (Interleukin 33 (IL33))

Reaktivität: Human, Maus

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser IL-33 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Produktdetails anti-IL-33 Antikörper

Aufreinigung: Immunoaffinity chromotography purified IgG

Immunogen: Raised against the recombinant IL-33 protein.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Lagerung: -20 °C

Informationen zur Lagerung: Can be stored at -20 °C, stable for one year.

Haltbarkeit: 12 months

Details zu IL-33

Target: IL-33 (IL33) (Interleukin 33 (IL33))

Andere Bezeichnung: IL-33

Hintergrund: Interleukin-33 (IL-33) is a recently identified member of the IL-1 family of cytokines whose other members include IL-1alphabeta, IL-1Ra and IL-18.Its receptor has been shown to be ST2, an IL-1 receptor family member that also acts as a negative regulator of TLR-IL-1R signaling and IL-1R accessory protein (IL-1RAcP).Receptor binding of IL-33 activates NF-kappaB and MAP kinases and induces the expression of TH2-associated cytokines such as IL-4, IL-5 and IL-6.Prolonged IL-33 treatment of mice led to the development of eosinophilia, splenomegaly, and severe pathological changes in mucosal organs such as lungs, esophagus and small intestine.Recent experiments have shown that IL-33 can also co-localize with heterochromatin and possesses transcriptional repressor activities, indicating that IL-33 may function as both a proinflammatory cytokine and an intracellular nuclear factor with transcriptional regulatory properties.Despite its predicted molecular weight, IL-33 will often run at higher molecular weight in SDS-PAGE.
Synonyms: IL-33 (12B3C4), Interleukin-33, Nuclear factor from high endothelial venules, NFHEV

NCBI Accession: NP_254274

Pathways: Production of Molecular Mediator of Immune Response