Phospholamban Antikörper (N-Term)

Produktnummer ABIN1882182

Dieses Anti-Phospholamban-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von Phospholamban in WB. Geeignet für Human. Dieses Primary Antibody wurde in 4+ Publikationen zitiert.

Kurzübersicht für Phospholamban Antikörper (N-Term) (ABIN1882182)

Target: Phospholamban (PLN)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Phospholamban Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: RB44799

Produktdetails anti-Phospholamban Antikörper

Bindungsspezifität: AA 1-22, N-Term

Homologie: B, M, Pig, Rb, Rat

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This PLN antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 1-22 amino acids from the N-terminal region of human PLN.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Referenzen für anti-Phospholamban Antikörper (ABIN1882182)

Kaliman, Catalucci, Lam, Kondo, Gutiérrez, Reddy, Palacín, Zorzano, Chien, Ruiz-Lozano: "Myotonic dystrophy protein kinase phosphorylates phospholamban and regulates calcium uptake in cardiomyocyte sarcoplasmic reticulum." in: The Journal of biological chemistry, Vol. 280, Issue 9, pp. 8016-21, (2005) (PubMed).

Minamisawa, Sato, Tatsuguchi, Fujino, Imamura, Uetsuka, Nakazawa, Matsuoka: "Mutation of the phospholamban promoter associated with hypertrophic cardiomyopathy." in: Biochemical and biophysical research communications, Vol. 304, Issue 1, pp. 1-4, (2003) (PubMed).

McTiernan, Frye, Lemster, Kinder, Ogletree-Hughes, Moravec, Feldman: "The human phospholamban gene: structure and expression." in: Journal of molecular and cellular cardiology, Vol. 31, Issue 3, pp. 679-92, (1999) (PubMed).

Fujii, Zarain-Herzberg, Willard, Tada, MacLennan: "Structure of the rabbit phospholamban gene, cloning of the human cDNA, and assignment of the gene to human chromosome 6." in: The Journal of biological chemistry, Vol. 266, Issue 18, pp. 11669-75, (1991) (PubMed).

Details zu Phospholamban

Target: Phospholamban (PLN)

Andere Bezeichnung: PLN

Hintergrund: Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2 Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. ATP2A2 inhibition is alleviated by PLN phosphorylation.

Molekulargewicht: 6109

UniProt: P26678

Pathways: Negative Regulation of Transporter Activity