GSG2 Antikörper (AA 323-352)

Produktnummer ABIN1882168

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch GSG2 in WB und IHC (p). Er zeigt eine Reaktivität gegenüber Human und wurde in 3+ Publikationen erwähnt.

Kurzübersicht für GSG2 Antikörper (AA 323-352) (ABIN1882168)

Target: GSG2 (Germ Cell Associated 2 (Haspin) (GSG2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GSG2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: RB3404

Produktdetails anti-GSG2 Antikörper

Bindungsspezifität: AA 323-352

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This Haspin GSG2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 323~352 amino acids from the central region of human haspin.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000. IHC-P: 1:50~100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Referenzen für anti-GSG2 Antikörper (ABIN1882168)

Dai, Sultan, Taylor, Higgins: "The kinase haspin is required for mitotic histone H3 Thr 3 phosphorylation and normal metaphase chromosome alignment." in: Genes & development, Vol. 19, Issue 4, pp. 472-88, (2005) (PubMed).

Higgins: "The Haspin gene: location in an intron of the integrin alphaE gene, associated transcription of an integrin alphaE-derived RNA and expression in diploid as well as haploid cells." in: Gene, Vol. 267, Issue 1, pp. 55-69, (2001) (PubMed).

Tanaka, Iguchi, Nakamura, Kohroki, de Carvalho, Nishimune: "Cloning and characterization of human haspin gene encoding haploid germ cell-specific nuclear protein kinase." in: Molecular human reproduction, Vol. 7, Issue 3, pp. 211-8, (2001) (PubMed).

Details zu GSG2

Target: GSG2 (Germ Cell Associated 2 (Haspin) (GSG2))

Andere Bezeichnung: Haspin GSG2

Hintergrund: Post-translational modifications of conserved N-terminal tail residues in histones regulate many aspects of chromosome activity. Mitotic phosphorylation of H3 Thr 3 occurs in prophase and dephosphorylation during anaphase. Haspin, a dual serine/threonine kinase, plays an important role in regulation of chromosome and spindle function during mitosis and meiosis via its function in phosphorylation of the threonine residue in the third position of histone 3 (Thr3).

Molekulargewicht: 88495

NCBI Accession: NP_114171

UniProt: Q8TF76