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DAPK2 Antikörper (N-Term)

Der Kaninchen Polyklonal Anti-DAPK2-Antikörper wurde für WB und IHC (p) validiert. Er ist geeignet, DAPK2 in Proben von Human und Maus zu detektieren. Es sind 6+ Publikationen verfügbar.
Produktnummer ABIN1882166

Kurzübersicht für DAPK2 Antikörper (N-Term) (ABIN1882166)

Target

Alle DAPK2 Antikörper anzeigen
DAPK2 (Death-Associated Protein Kinase 2 (DAPK2))

Reaktivität

  • 63
  • 29
  • 13
  • 1
  • 1
Human, Maus

Wirt

  • 55
  • 7
  • 1
Kaninchen

Klonalität

  • 55
  • 8
Polyklonal

Konjugat

  • 35
  • 5
  • 4
  • 4
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser DAPK2 Antikörper ist unkonjugiert

Applikation

  • 50
  • 34
  • 21
  • 13
  • 13
  • 13
  • 12
  • 7
  • 4
  • 3
  • 2
  • 2
  • 1
Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon

RB3053
  • Bindungsspezifität

    • 18
    • 7
    • 7
    • 6
    • 4
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1-30, N-Term

    Aufreinigung

    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

    Immunogen

    This DAPK2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human DAPK2.

    Isotyp

    Ig Fraction
  • Applikationshinweise

    WB: 1:1000. WB: 1:2000. IHC-P: 1:50~100

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Buffer

    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    4 °C,-20 °C

    Haltbarkeit

    6 months
  • Cai, Cao, Zhang, Xue, Zhang, Zhou, Zhou, Sun, Fu: "Oncogenic miR-17/20a Forms a Positive Feed-forward Loop with the p53 Kinase DAPK3 to Promote Tumorigenesis." in: The Journal of biological chemistry, Vol. 290, Issue 32, pp. 19967-75, (2015) (PubMed).

    Karur, Lowell, Besmer, Agosti, Wojchowski: "Lyn kinase promotes erythroblast expansion and late-stage development." in: Blood, Vol. 108, Issue 5, pp. 1524-32, (2006) (PubMed).

    Satoh, Toyota, Itoh, Kikuchi, Obata, Sasaki, Suzuki, Yawata, Kusano, Fujita, Hosokawa, Yanagihara, Tokino, Imai: "DNA methylation and histone deacetylation associated with silencing DAP kinase gene expression in colorectal and gastric cancers." in: British journal of cancer, Vol. 86, Issue 11, pp. 1817-23, (2002) (PubMed).

    Chan, Chan, Tang, Tong, Lo, Lee, Cheung, Wong, Chan, Lai, To: "Hypermethylation of multiple genes in tumor tissues and voided urine in urinary bladder cancer patients." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 8, Issue 2, pp. 464-70, (2002) (PubMed).

    Wong, Chang, Tang, Wei, Kwong, Sham, Yuen, Kwong: "High frequency of promoter hypermethylation of the death-associated protein-kinase gene in nasopharyngeal carcinoma and its detection in the peripheral blood of patients." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 8, Issue 2, pp. 433-7, (2002) (PubMed).

    Shani, Henis-Korenblit, Jona, Gileadi, Eisenstein, Ziv, Admon, Kimchi: "Autophosphorylation restrains the apoptotic activity of DRP-1 kinase by controlling dimerization and calmodulin binding." in: The EMBO journal, Vol. 20, Issue 5, pp. 1099-113, (2001) (PubMed).

  • Target

    DAPK2 (Death-Associated Protein Kinase 2 (DAPK2))

    Andere Bezeichnung

    DAPK2

    Hintergrund

    DAPK2 belongs to the serine/threonine protein kinase family. This protein contains a N-terminal protein kinase domain followed by a conserved calmodulin-binding domain with significant similarity to that of death-associated protein kinase 1 (DAPK1), a positive regulator of programmed cell death. Overexpression of this gene was shown to induce cell apoptosis. It uses multiple polyadenylation sites.

    Molekulargewicht

    42898

    NCBI Accession

    NP_055141

    UniProt

    Q9UIK4
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