ZHX1 Antikörper (C-Term)

Produktnummer ABIN1882010

Der Kaninchen Polyklonal Anti-ZHX1-Antikörper wurde für WB validiert. Er ist geeignet, ZHX1 in Proben von Human zu detektieren. Es sind 4+ Publikationen verfügbar.

Kurzübersicht für ZHX1 Antikörper (C-Term) (ABIN1882010)

Target: ZHX1 (Zinc Fingers and Homeoboxes 1 (ZHX1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ZHX1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: RB40545

Produktdetails anti-ZHX1 Antikörper

Bindungsspezifität: AA 771-800, C-Term

Homologie: M, Rat

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This ZHX1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 771-800 amino acids from the C-terminal region of human ZHX1.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Referenzen für anti-ZHX1 Antikörper (ABIN1882010)

Wienk, Lammers, Hotze, Wu, Wechselberger, Owens, Stammers, Stuart, Kaptein, Folkers: "The tandem zinc-finger region of human ZHX adopts a novel C2H2 zinc finger structure with a C-terminal extension." in: Biochemistry, Vol. 48, Issue 21, pp. 4431-9, (2009) (PubMed).

Kim, Park, Choi, Kim, Park, Jung, Lee, Oh, Im, Bang, Kim: "Zinc-fingers and homeoboxes 1 (ZHX1) binds DNA methyltransferase (DNMT) 3B to enhance DNMT3B-mediated transcriptional repression." in: Biochemical and biophysical research communications, Vol. 355, Issue 2, pp. 318-23, (2007) (PubMed).

Matsuoka, Ballif, Smogorzewska, McDonald, Hurov, Luo, Bakalarski, Zhao, Solimini, Lerenthal, Shiloh, Gygi, Elledge: "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage." in: Science (New York, N.Y.), Vol. 316, Issue 5828, pp. 1160-6, (2007) (PubMed).

Liu, Clement, Kanwar, Avila-Casado, Chugh: "ZHX proteins regulate podocyte gene expression during the development of nephrotic syndrome." in: The Journal of biological chemistry, Vol. 281, Issue 51, pp. 39681-92, (2006) (PubMed).

Details zu ZHX1

Target: ZHX1 (Zinc Fingers and Homeoboxes 1 (ZHX1))

Andere Bezeichnung: ZHX1

Hintergrund: The members of the zinc fingers and homeoboxes gene family are nuclear homodimeric transcriptional repressors that interact with the A subunit of nuclear factor-Y (NF-YA) and contain two C2H2-type zinc fingers and five homeobox DNA-binding domains. This gene encodes member 1 of this gene family. In addition to forming homodimers, this protein heterodimerizes with members 2 and 3 of the zinc fingers and homeoboxes family. Alternative splicing results in multiple transcript variants encoding the same protein.

Molekulargewicht: 98098

NCBI Accession: NP_001017926, NP_009153

UniProt: Q9UKY1