USP14 Antikörper (C-Term)

Produktnummer ABIN1881985

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch USP14 in WB. Er zeigt eine Reaktivität gegenüber Human und wurde in 6+ Publikationen erwähnt.

Kurzübersicht für USP14 Antikörper (C-Term) (ABIN1881985)

Target: USP14 (Ubiquitin Specific Peptidase 14 (USP14))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser USP14 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: RB41691

Produktdetails anti-USP14 Antikörper

Bindungsspezifität: AA 355-383, C-Term

Homologie: B, M

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This USP14 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 355-383 amino acids from the C-terminal region of human USP14.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Referenzen für anti-USP14 Antikörper (ABIN1881985)

Hyrskyluoto, Bruelle, Lundh, Do, Kivinen, Rappou, Reijonen, Waltimo, Petersén, Lindholm, Korhonen: "Ubiquitin-specific protease-14 reduces cellular aggregates and protects against mutant huntingtin-induced cell degeneration: involvement of the proteasome and ER stress-activated kinase IRE1?." in: Human molecular genetics, Vol. 23, Issue 22, pp. 5928-39, (2014) (PubMed).

Davila, Froeling, Tan, Bonnard, Boland, Snippe, Hibberd, Seielstad: "New genetic associations detected in a host response study to hepatitis B vaccine." in: Genes and immunity, Vol. 11, Issue 3, pp. 232-8, (2010) (PubMed).

Chen, Qin, Li, Walters, Wilson, Mei, Wilson: "The proteasome-associated deubiquitinating enzyme Usp14 is essential for the maintenance of synaptic ubiquitin levels and the development of neuromuscular junctions." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 29, Issue 35, pp. 10909-19, (2009) (PubMed).

Nagai, Kadowaki, Maruyama, Takeda, Nishitoh, Ichijo: "USP14 inhibits ER-associated degradation via interaction with IRE1alpha." in: Biochemical and biophysical research communications, Vol. 379, Issue 4, pp. 995-1000, (2009) (PubMed).

Mines, Goodwin, Limbird, Cui, Fan: "Deubiquitination of CXCR4 by USP14 is critical for both CXCL12-induced CXCR4 degradation and chemotaxis but not ERK ativation." in: The Journal of biological chemistry, Vol. 284, Issue 9, pp. 5742-52, (2009) (PubMed).

Koulich, Li, DeMartino: "Relative structural and functional roles of multiple deubiquitylating proteins associated with mammalian 26S proteasome." in: Molecular biology of the cell, Vol. 19, Issue 3, pp. 1072-82, (2008) (PubMed).

Details zu USP14

Target: USP14 (Ubiquitin Specific Peptidase 14 (USP14))

Andere Bezeichnung: USP14

Hintergrund: This gene encodes a member of the ubiquitin-specific processing (UBP) family of proteases that is a deubiquitinating enzyme (DUB) with His and Cys domains. This protein is located in the cytoplasm and cleaves the ubiquitin moiety from ubiquitin-fused precursors and ubiquitinylated proteins. Mice with a mutation that results in reduced expression of the ortholog of this protein are retarded for growth, develop severe tremors by 2 to 3 weeks of age followed by hindlimb paralysis and death by 6 to 10 weeks of age. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Molekulargewicht: 56069

NCBI Accession: NP_001032411, NP_005142

UniProt: P54578