TXN Antikörper (C-Term)

Produktnummer ABIN1881960

Dieses Anti-TXN-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von TXN in WB und IHC (p). Geeignet für Human. Dieses Primary Antibody wurde in 1 Publikation zitiert.

Kurzübersicht für TXN Antikörper (C-Term) (ABIN1881960)

Target: TXN (Thioredoxin (TXN))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TXN Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: RB42816

Produktdetails anti-TXN Antikörper

Bindungsspezifität: AA 66-94, C-Term

Homologie: B, M, Pig, Rb, Rat

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This TXN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 66-94 amino acids from the C-terminal region of human TXN.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000. IHC-P: 1:25. IHC-P: 1:25

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Referenzen für anti-TXN Antikörper (ABIN1881960)

Zheng, Ma, Sun, Yin, Lin, Liu, Xu, Zeng: "Butaselen prevents hepatocarcinogenesis and progression through inhibiting thioredoxin reductase activity." in: Redox biology, Vol. 14, pp. 237-249, (2018) (PubMed).

Details zu TXN

Target: TXN (Thioredoxin (TXN))

Andere Bezeichnung: TXN

Hintergrund: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA-binding activity in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates AP-1 transcriptional activity. ADF augments the expression of the interleukin-2 receptor TAC (IL2R/P55).

Molekulargewicht: 11737

NCBI Accession: NP_001231867, NP_003320

UniProt: P10599

Pathways: Carbohydrate Homeostasis, Cell RedoxHomeostasis