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TNNC2 Antikörper (C-Term)

Dieses Anti-TNNC2-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von TNNC2 in WB. Geeignet für Human und Maus. Dieses Primary Antibody wurde in 5+ Publikationen zitiert.
Produktnummer ABIN1881894

Kurzübersicht für TNNC2 Antikörper (C-Term) (ABIN1881894)

Target

Alle TNNC2 Antikörper anzeigen
TNNC2 (Fast Skeletal Troponin C (TNNC2))

Reaktivität

  • 31
  • 20
  • 3
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
Human, Maus

Wirt

  • 30
  • 1
Kaninchen

Klonalität

  • 31
Polyklonal

Konjugat

  • 15
  • 6
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser TNNC2 Antikörper ist unkonjugiert

Applikation

  • 24
  • 14
  • 10
  • 5
  • 3
  • 1
Western Blotting (WB)

Klon

RB32470
  • Bindungsspezifität

    • 8
    • 5
    • 3
    • 1
    • 1
    • 1
    AA 97-126, C-Term

    Aufreinigung

    This antibody is purified through a protein A column, followed by peptide affinity purification.

    Immunogen

    This TNNC2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 97-126 amino acids from the C-terminal region of human TNNC2.

    Isotyp

    Ig Fraction
  • Applikationshinweise

    WB: 1:1000. WB: 1:1000

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Buffer

    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    4 °C,-20 °C

    Haltbarkeit

    6 months
  • Bailey, Xie, Do, Montpetit, Diaz, Mohan, Keavney, Yusuf, Gerstein, Engert, Anand: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, (2010) (PubMed).

    Talmud, Drenos, Shah, Shah, Palmen, Verzilli, Gaunt, Pallas, Lovering, Li, Casas, Sofat, Kumari, Rodriguez, Johnson, Newhouse, Dominiczak, Samani, Caulfield, Sever, Stanton, Shields, Padmanabhan et al.: "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. ..." in: American journal of human genetics, Vol. 85, Issue 5, pp. 628-42, (2009) (PubMed).

    Robinson, Lipscomb, Preston, Altin, Watkins, Ashley, Redwood: "Mutations in fast skeletal troponin I, troponin T, and beta-tropomyosin that cause distal arthrogryposis all increase contractile function." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 21, Issue 3, pp. 896-905, (2007) (PubMed).

    Deloukas, Matthews, Ashurst, Burton, Gilbert, Jones, Stavrides, Almeida, Babbage, Bagguley, Bailey, Barlow, Bates, Beard, Beare, Beasley, Bird, Blakey, Bridgeman, Brown, Buck, Burrill, Butler, Carder et al.: "The DNA sequence and comparative analysis of human chromosome 20. ..." in: Nature, Vol. 414, Issue 6866, pp. 865-71, (2002) (PubMed).

    Vassylyev, Takeda, Wakatsuki, Maeda, Maéda: "Crystal structure of troponin C in complex with troponin I fragment at 2.3-A resolution." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 95, Issue 9, pp. 4847-52, (1998) (PubMed).

  • Target

    TNNC2 (Fast Skeletal Troponin C (TNNC2))

    Andere Bezeichnung

    TNNC2

    Hintergrund

    Troponin (Tn), a key protein complex in the regulation of striated muscle contraction, is composed of 3 subunits. The Tn-I subunit inhibits actomyosin ATPase, the Tn-T subunit binds tropomyosin and Tn-C, while the Tn-C subunit binds calcium and overcomes the inhibitory action of the troponin complex on actin filaments. The protein encoded by this gene is the Tn-C subunit.

    Molekulargewicht

    18122

    NCBI Accession

    NP_003270

    UniProt

    P02585
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