TIPIN Antikörper (N-Term)

Produktnummer ABIN1881887

Der Kaninchen Polyklonal Anti-TIPIN-Antikörper wurde für WB validiert. Er ist geeignet, TIPIN in Proben von Human zu detektieren. Es sind 3+ Publikationen verfügbar.

Kurzübersicht für TIPIN Antikörper (N-Term) (ABIN1881887)

Target: TIPIN (TIMELESS Interacting Protein (TIPIN))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TIPIN Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: RB40607

Produktdetails anti-TIPIN Antikörper

Bindungsspezifität: AA 227-254, N-Term

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This TIPIN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 227-254 amino acids from the N-terminal region of human TIPIN.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Referenzen für anti-TIPIN Antikörper (ABIN1881887)

Kemp, Akan, Yilmaz, Grillo, Smith-Roe, Kang, Cordeiro-Stone, Kaufmann, Abraham, Sancar, Unsal-Kaçmaz: "Tipin-replication protein A interaction mediates Chk1 phosphorylation by ATR in response to genotoxic stress." in: The Journal of biological chemistry, Vol. 285, Issue 22, pp. 16562-71, (2010) (PubMed).

Leman, Noguchi, Lee, Noguchi: "Human Timeless and Tipin stabilize replication forks and facilitate sister-chromatid cohesion." in: Journal of cell science, Vol. 123, Issue Pt 5, pp. 660-70, (2010) (PubMed).

Gotter, Suppa, Emanuel: "Mammalian TIMELESS and Tipin are evolutionarily conserved replication fork-associated factors." in: Journal of molecular biology, Vol. 366, Issue 1, pp. 36-52, (2007) (PubMed).

Details zu TIPIN

Target: TIPIN (TIMELESS Interacting Protein (TIPIN))

Andere Bezeichnung: TIPIN

Hintergrund: Required for normal progression of S-phase. Important for cell survival after DNA damage or replication stress. May be specifically required for the ATR-CHK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light.

Molekulargewicht: 34555

NCBI Accession: NP_060328

UniProt: Q9BVW5