TIAM1 Antikörper (C-Term)

Produktnummer ABIN1881884

Der Kaninchen Polyklonal Anti-TIAM1-Antikörper wurde für WB validiert. Er ist geeignet, TIAM1 in Proben von Human zu detektieren. Es sind 3+ Publikationen verfügbar.

Kurzübersicht für TIAM1 Antikörper (C-Term) (ABIN1881884)

Target: TIAM1 (T-Cell Lymphoma Invasion and Metastasis 1 (TIAM1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TIAM1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: RB41848

Produktdetails anti-TIAM1 Antikörper

Bindungsspezifität: AA 1478-1506, C-Term

Homologie: M

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This TIAM1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1478-1506 amino acids from the C-terminal region of human TIAM1.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Referenzen für anti-TIAM1 Antikörper (ABIN1881884)

Yang, Lv, Liu, Liu, Yang, Hu: "Up-regulation of Tiam1 and Rac1 correlates with poor prognosis in hepatocellular carcinoma." in: Japanese journal of clinical oncology, Vol. 40, Issue 11, pp. 1053-9, (2010) (PubMed).

Moriarty, Pursell, Mercurio: "miR-10b targets Tiam1: implications for Rac activation and carcinoma migration." in: The Journal of biological chemistry, Vol. 285, Issue 27, pp. 20541-6, (2010) (PubMed).

Shepherd, Klaus, Liu, Ramaswamy, DeMali, Fuentes: "The Tiam1 PDZ domain couples to Syndecan1 and promotes cell-matrix adhesion." in: Journal of molecular biology, Vol. 398, Issue 5, pp. 730-46, (2010) (PubMed).

Details zu TIAM1

Target: TIAM1 (T-Cell Lymphoma Invasion and Metastasis 1 (TIAM1))

Andere Bezeichnung: TIAM1

Hintergrund: Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP-dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Activates RAC1, CDC42, and to a lesser extent RHOA.

Molekulargewicht: 177508

NCBI Accession: NP_003244

UniProt: Q13009