SPANXB1 Antikörper (AA 17-47)

Produktnummer ABIN1881824

Der Kaninchen Polyklonal Anti-SPANXB1-Antikörper wurde für WB validiert. Er ist geeignet, SPANXB1 in Proben von Human zu detektieren. Es sind 4+ Publikationen verfügbar.

Kurzübersicht für SPANXB1 Antikörper (AA 17-47) (ABIN1881824)

Target: SPANXB1 (SPANX Family, Member B1 (SPANXB1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SPANXB1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: RB42680

Produktdetails anti-SPANXB1 Antikörper

Bindungsspezifität: AA 17-47

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This SPNXB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 17-47 amino acids from the Central region of human SPNXB.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Referenzen für anti-SPANXB1 Antikörper (ABIN1881824)

Hansen, Eichler, Fullerton, Carrell: "SPANX gene variation in fertile and infertile males." in: Systems biology in reproductive medicine, Vol. 55, pp. 18-26, (2010) (PubMed).

Hansen, Nielsen, Retelska, Larsen, Leffers: "A shared promoter region suggests a common ancestor for the human VCX/Y, SPANX, and CSAG gene families and the murine CYPT family." in: Molecular reproduction and development, Vol. 75, Issue 2, pp. 219-29, (2007) (PubMed).

Kouprina, Pavlicek, Noskov, Solomon, Otstot, Isaacs, Carpten, Trent, Schleutker, Barrett, Jurka, Larionov: "Dynamic structure of the SPANX gene cluster mapped to the prostate cancer susceptibility locus HPCX at Xq27." in: Genome research, Vol. 15, Issue 11, pp. 1477-86, (2005) (PubMed).

Zendman, Zschocke, van Kraats, de Wit, Kurpisz, Weidle, Ruiter, Weiss, van Muijen: "The human SPANX multigene family: genomic organization, alignment and expression in male germ cells and tumor cell lines." in: Gene, Vol. 309, Issue 2, pp. 125-33, (2003) (PubMed).

Details zu SPANXB1

Target: SPANXB1 (SPANX Family, Member B1 (SPANXB1))

Hintergrund: Temporally regulated transcription and translation of several testis-specific genes is required to initiate the series of molecular and morphological changes in the male germ cell lineage necessary for the formation of mature spermatozoa. This gene is a member of the SPANX family of cancer/testis-associated genes, which are located in a cluster on chromosome X. The SPANX genes encode differentially expressed testis-specific proteins that localize to various subcellular compartments. This particular gene maps to chromosome X in a head-to-tail orientation with SPANX family member B1 and appears to be a duplication of that locus. The SPANXB genes are unique members of this gene family, since they contain an additional 18 nt in their coding region compared to the majority of family members. Although the protein encoded by this gene contains consensus nuclear localization signals, the major site for subcellular localization of expressed protein is in the cytoplasmic droplets of ejaculated spermatozoa. This protein provides a biochemical marker for studying the unique structures in spermatazoa, while attempting to further define its role in spermatogenesis.

Molekulargewicht: 11840

NCBI Accession: NP_115850, NP_620588, NP_663697

UniProt: Q9NS25